• Gene id: 133

Gene Summary

• Gene Symbol: ADM   Gene   UCSC   Ensembl
• Aliases: AM, PAMP
• Gene name: adrenomedullin
• Alternate names: ADM, preproadrenomedullin, proadrenomedullin N-20 terminal peptide,
• Gene location: 11p15.4 (10304979: 10307401)     Exons: 4     NC_000011.10
• Gene summary(Entrez): The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, re
• OMIM: 103275

SNPs

rs11749327

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000005.10   g.457146C>A
NC_000005.9   g.457261C>A|SEQ=[C/A]|GENE=EXOC3

Protein Summary

• Protein general information: P35318  
  • Name: ADM [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N 20 terminal peptide (ProAM N terminal 20 peptide) (PAMP) (ProAM N20)]
  • Length: 185  
  • Mass: 20,420
  • Tissue specificity: Testis-specific. {ECO
• Sequence:

  MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPAQTLIRPQDMKG
  ASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGYGRRR
  RRSLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL

• Structural information:
  • Interpro: IPR001710  IPR021116  
  • PDB: 2FLY 2L7S 4RWF 5V6Y
  • PDBsum: 2FLY 2L7S 4RWF 5V6Y
  • STRING: ENSP00000278175
• Other Databases: GeneCards:  ADM  Malacards:  ADM

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001570	vasculogenesis	IDA	biological process
GO:0001666	response to hypoxia	IEA	biological process
GO:0001843	neural tube closure	IEA	biological process
GO:0002026	regulation of the force of heart contraction	IEA	biological process
GO:0002031	G-protein coupled receptor internalization	IDA	biological process
GO:0005102	receptor binding	TAS	molecular function
GO:0005102	receptor binding	TAS	molecular function
GO:0005179	hormone activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006701	progesterone biosynthetic process	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0007507	heart development	IEA	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0007568	aging	IEA	biological process
GO:0008015	blood circulation	TAS	biological process
GO:0008209	androgen metabolic process	IEA	biological process
GO:0008284	positive regulation of cell proliferation	IEA	biological process
GO:0008285	negative regulation of cell proliferation	IEA	biological process
GO:0009409	response to cold	IEA	biological process
GO:0009611	response to wounding	IEA	biological process
GO:0010460	positive regulation of heart rate	IEA	biological process
GO:0019731	antibacterial humoral response	IDA	biological process
GO:0019933	cAMP-mediated signaling	IEA	biological process
GO:0030819	positive regulation of cAMP biosynthetic process	IDA	biological process
GO:0031100	animal organ regeneration	IEA	biological process
GO:0031102	neuron projection regeneration	IEA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031700	adrenomedullin receptor binding	IEA	molecular function
GO:0032496	response to lipopolysaccharide	IEA	biological process
GO:0032868	response to insulin	IEA	biological process
GO:0042475	odontogenesis of dentin-containing tooth	IEA	biological process
GO:0042594	response to starvation	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043116	negative regulation of vascular permeability	IEA	biological process
GO:0045766	positive regulation of angiogenesis	IEA	biological process
GO:0045906	negative regulation of vasoconstriction	IDA	biological process
GO:0045909	positive regulation of vasodilation	IEA	biological process
GO:0046879	hormone secretion	IEA	biological process
GO:0048589	developmental growth	IEA	biological process
GO:0050829	defense response to Gram-negative bacterium	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0060670	branching involved in labyrinthine layer morphogenesis	IEA	biological process
GO:0060712	spongiotrophoblast layer development	IEA	biological process
GO:0097084	vascular smooth muscle cell development	IEA	biological process
GO:2001214	positive regulation of vasculogenesis	IEA	biological process
GO:0001878	response to yeast	IDA	biological process
GO:0019732	antifungal humoral response	IDA	biological process
GO:0001570	vasculogenesis	IDA	biological process
GO:0001666	response to hypoxia	IEA	biological process
GO:0001843	neural tube closure	IEA	biological process
GO:0002026	regulation of the force of heart contraction	IEA	biological process
GO:0002031	G-protein coupled receptor internalization	IDA	biological process
GO:0005102	receptor binding	TAS	molecular function
GO:0005102	receptor binding	TAS	molecular function
GO:0005179	hormone activity	IEA	molecular function
GO:0005179	hormone activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	TAS	biological process
GO:0006701	progesterone biosynthetic process	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0007507	heart development	IEA	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0007565	female pregnancy	TAS	biological process
GO:0007568	aging	IEA	biological process
GO:0008015	blood circulation	TAS	biological process
GO:0008209	androgen metabolic process	IEA	biological process
GO:0008284	positive regulation of cell proliferation	IEA	biological process
GO:0008285	negative regulation of cell proliferation	IEA	biological process
GO:0009409	response to cold	IEA	biological process
GO:0009611	response to wounding	IEA	biological process
GO:0009611	response to wounding	TAS	biological process
GO:0010033	response to organic substance	IEA	biological process
GO:0010460	positive regulation of heart rate	IEA	biological process
GO:0019731	antibacterial humoral response	IDA	biological process
GO:0019933	cAMP-mediated signaling	IEA	biological process
GO:0030819	positive regulation of cAMP biosynthetic process	IDA	biological process
GO:0031100	animal organ regeneration	IEA	biological process
GO:0031102	neuron projection regeneration	IEA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031700	adrenomedullin receptor binding	IEA	molecular function
GO:0032496	response to lipopolysaccharide	IEA	biological process
GO:0032868	response to insulin	IEA	biological process
GO:0042475	odontogenesis of dentin-containing tooth	IEA	biological process
GO:0042594	response to starvation	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043116	negative regulation of vascular permeability	IEA	biological process
GO:0045766	positive regulation of angiogenesis	IEA	biological process
GO:0045906	negative regulation of vasoconstriction	IDA	biological process
GO:0045909	positive regulation of vasodilation	IEA	biological process
GO:0046879	hormone secretion	IEA	biological process
GO:0048589	developmental growth	IEA	biological process
GO:0050829	defense response to Gram-negative bacterium	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0055074	calcium ion homeostasis	IEA	biological process
GO:0060670	branching involved in labyrinthine layer morphogenesis	IEA	biological process
GO:0060712	spongiotrophoblast layer development	IEA	biological process
GO:0097084	vascular smooth muscle cell development	IEA	biological process
GO:2001214	positive regulation of vasculogenesis	IEA	biological process
GO:0001878	response to yeast	IDA	biological process
GO:0019732	antifungal humoral response	IDA	biological process
GO:0001570	vasculogenesis	IDA	biological process
GO:0002031	G-protein coupled receptor internalization	IDA	biological process
GO:0005102	receptor binding	TAS	molecular function
GO:0005102	receptor binding	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006171	cAMP biosynthetic process	IDA	biological process
GO:0006171	cAMP biosynthetic process	TAS	biological process
GO:0006701	progesterone biosynthetic process	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0007565	female pregnancy	TAS	biological process
GO:0008015	blood circulation	TAS	biological process
GO:0009611	response to wounding	TAS	biological process
GO:0019731	antibacterial humoral response	IDA	biological process
GO:0030819	positive regulation of cAMP biosynthetic process	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0045906	negative regulation of vasoconstriction	IDA	biological process
GO:0050829	defense response to Gram-negative bacterium	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0001878	response to yeast	IDA	biological process
GO:0019732	antifungal humoral response	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04270	Vascular smooth muscle contraction

Diseases

Associated diseases	References
Blood pressure	GAD: 16609682
Hypertension	GAD: 16097366
Cerebral infarction	GAD: 17922433
Diabetes	GAD: 12753312
Bipolar disorder	GAD: 20713499
Schizophrenia	GAD: 20713499
Chronic renal failure	GAD: 21085059
Female infertility	INFBASE: 21791966
Pregnancy failure	INFBASE: 20170350
Polycystic ovary syndrome (PCOS)	INFBASE: 18851710
Unexplained infertility	INFBASE: 20954838
Male factor infertility	MIK: 16854513
Sperm motility	MIK: 15908101
Azoospermia	MIK: 16854513
Progressive motility	MIK: 21990183
Varicocele	MIK: 25335788
Oligozoospermia	MIK: 16854513
Male factor infertility	MIK: 25335788
Zona pellucida-binding capacity of spermatozoa	MIK: 21990183
Asthenozoospermia	MIK: 21990183
Male infertility	MIK: 16854513
Oligozoospermia	MIK: 16854513
Azoospermia	MIK: 16854513
Progressive motility	MIK: 21990183
Zona pellucida-binding capacity of spermatozoa	MIK: 21990183
Asthenozoospermia	MIK: 21990183
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Varicocele	MIK: 25335788

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25335788	Varicocele			65 (30 fertile VC subjects and 35 untreated infertile VC patients)	Male infertility
16854513	Male infertility, oligozoospermia, azoospermia			51 (19 normospermic, 17 oligozoospermic, 15 azoospermic)	Male infertility
15908101	Sperm motility, male infertility			19 obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA	Male infertility
21990183	Progressive motility, zona pellucida-binding capacity of spermatozoa, Asthenozoospermia				Male Infertility	Adrenomedullin
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R