• Gene id: 131450

Gene Summary

• Gene Symbol: CD200R1   Gene   UCSC   Ensembl
• Aliases: CD200R, HCRTR2, MOX2R, OX2R
• Gene name: CD200 receptor 1
• Alternate names: cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, MOX2 receptor, cell surface glycoprotein OX2 receptor 1, cell surface glycoprotein receptor CD200,
• Gene location: 3q13.2 (112975102: 112921204)     Exons: 8     NC_000003.12
• Gene summary(Entrez): This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the recept
• OMIM: 613441

Protein Summary

• Protein general information: Q8TD46  
  • Name: Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)
  • Length: 325  
  • Mass: 36620
  • Tissue specificity: Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-d
• Sequence:

  MLCPWRTANLGLLLILTIFLVAASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWE
  IILRGQPSCTKAYRKETNETKETNCTDERITWVSRPDQNSDLQIRPVAITHDGYYRCIMVTPDGNFHRGYHLQVL
  VTPEVTLFQNRNRTAVCKAVAGKPAAQISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNK
  SLYIELLPVPGAKKSAKLYIPYIILTIIILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNP
  LYDTTNKVKASEALQSEVDTDLHTL

• Structural information:
  • Protein Domains: (53..13-)
    (/note="Ig-like-V-type)
    (140..22-)
    (/note="Ig-like-C2-type")
  • Interpro: IPR040012  IPR013162  IPR007110  IPR036179  IPR013783  
  • Prosite: PS50835
  • STRING: ENSP00000311035
• Other Databases: GeneCards:  CD200R1  Malacards:  CD200R1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009986	cell surface	IDA	cellular component
GO:0140081	glycosylated region protein binding	TAS	molecular function
GO:0019763	immunoglobulin receptor activity	TAS	molecular function
GO:1901215	negative regulation of neuron death	ISS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:2000405	negative regulation of T cell migration	ISS	biological process
GO:0150077	regulation of neuroinflammatory response	ISS	biological process
GO:1900165	negative regulation of interleukin-6 secretion	ISS	biological process
GO:1905522	negative regulation of macrophage migration	ISS	biological process
GO:0150079	negative regulation of neuroinflammatory response	ISS	biological process
GO:0035556	intracellular signal transduction	TAS	biological process
GO:0009986	cell surface	ISS	cellular component
GO:0034113	heterotypic cell-cell adhesion	ISS	biological process
GO:0034113	heterotypic cell-cell adhesion	ISS	biological process
GO:0009897	external side of plasma membrane	IBA	cellular component
GO:0038023	signaling receptor activity	IBA	molecular function
GO:0038023	signaling receptor activity	IEA	molecular function
GO:0150077	regulation of neuroinflammatory response	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0043235	receptor complex	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0050776	regulation of immune response	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0038093	Fc receptor signaling pathway	IEA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0140081	glycosylated region protein binding	TAS	molecular function
GO:0019763	immunoglobulin receptor activity	TAS	molecular function
GO:1901215	negative regulation of neuron death	ISS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:2000405	negative regulation of T cell migration	ISS	biological process
GO:0150077	regulation of neuroinflammatory response	ISS	biological process
GO:1900165	negative regulation of interleukin-6 secretion	ISS	biological process
GO:1905522	negative regulation of macrophage migration	ISS	biological process
GO:0150079	negative regulation of neuroinflammatory response	ISS	biological process
GO:0035556	intracellular signal transduction	TAS	biological process
GO:0009986	cell surface	ISS	cellular component
GO:0034113	heterotypic cell-cell adhesion	ISS	biological process
GO:0034113	heterotypic cell-cell adhesion	ISS	biological process
GO:0009897	external side of plasma membrane	IBA	cellular component
GO:0038023	signaling receptor activity	IBA	molecular function
GO:0038023	signaling receptor activity	IEA	molecular function
GO:0150077	regulation of neuroinflammatory response	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0043235	receptor complex	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0050776	regulation of immune response	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0038093	Fc receptor signaling pathway	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa05167	Kaposi sarcoma-associated herpesvirus infection

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881