• Gene id: 129642

Gene Summary

• Gene Symbol: MBOAT2   Gene   UCSC   Ensembl
• Aliases: LPAAT, LPCAT4, LPEAT, LPLAT 2, OACT2
• Gene name: membrane bound O-acyltransferase domain containing 2
• Alternate names: lysophospholipid acyltransferase 2, 1-acylglycerophosphate O-acyltransferase, 1-acylglycerophosphoethanolamine O-acyltransferase, O-acyltransferase (membrane bound) domain containing 2, lyso-PA acyltransferase, lyso-PE acyltransferase, lysophosphatidic acid acy,
• Gene location: 2p25.1 (9003709: 8852689)     Exons: 15     NC_000002.12
• OMIM: 611949

Protein Summary

• Protein general information: Q6ZWT7  
  • Name: Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1. ) (1 acylglycerophosphate O acyltransferase) (EC 2.3.1.51) (1 acylglycerophosphoethanolamine O acyltransferase) (EC 2.3.1.n7) (Lysophosphatidic acid acyltransferase) (LPAAT) (Lyso PA acyltransferase)
  • Length: 520  
  • Mass: 59527
  • Tissue specificity: Expressed in neutrophils. {ECO
• Sequence:

  MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWY
  ALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHD
  GMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERT
  EPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINN
  AAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGV
  YPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYY
  CLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

• Structural information:
  • Interpro: IPR004299  
  • STRING: ENSP00000302177
• Other Databases: GeneCards:  MBOAT2  Malacards:  MBOAT2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030258	lipid modification	IBA	biological process
GO:0016746	transferase activity, transferring acyl groups	IBA	molecular function
GO:0016020	membrane	IBA	cellular component
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008654	phospholipid biosynthetic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	IEA	molecular function
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	TAS	biological process
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0036151	phosphatidylcholine acyl-chain remodeling	TAS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0006644	phospholipid metabolic process	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00564	Glycerophospholipid metabolism
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R