• Gene id: 129450

Gene Summary

• Gene Symbol: TYW5   Gene   UCSC   Ensembl
• Aliases: C2orf60, hTYW5
• Gene name: tRNA-yW synthesizing protein 5
• Alternate names: tRNA wybutosine-synthesizing protein 5, jmjC domain-containing protein C2orf60, tRNA yW-synthesizing enzyme 5, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase,
• Gene location: 2q33.1 (199955623: 199928912)     Exons: 8     NC_000002.12
• OMIM: 611309

Protein Summary

• Protein general information: A2RUC4  
  • Name: tRNA wybutosine synthesizing protein 5 (hTYW5) (EC 1.14.11.42) (tRNA(Phe) (7 (3 amino 3 carboxypropyl)wyosine(37) C(2)) hydroxylase)
  • Length: 315  
  • Mass: 36548
• Sequence:

  MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNF
  VYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRI
  SSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGD
  VLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARR
  MVLHIQDKAYSKNSE

• Structural information:
  • Protein Domains: (102..26-)
    (/note="JmjC-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00538"-)
  • Interpro: IPR041667  IPR003347  IPR029612  
  • Prosite: PS51184
  • PDB: 3AL5 3AL6
  • PDBsum: 3AL5 3AL6
  • STRING: ENSP00000346627
• Other Databases: GeneCards:  TYW5  Malacards:  TYW5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031591	wybutosine biosynthetic process	IBA	biological process
GO:0000049	tRNA binding	IBA	molecular function
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	IBA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	IDA	molecular function
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	IDA	molecular function
GO:0005506	iron ion binding	IDA	molecular function
GO:0000049	tRNA binding	IDA	molecular function
GO:0031591	wybutosine biosynthetic process	IDA	biological process
GO:0031591	wybutosine biosynthetic process	IDA	biological process
GO:0000049	tRNA binding	IEA	molecular function
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	IEA	molecular function
GO:0031591	wybutosine biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0051213	dioxygenase activity	IEA	molecular function
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0102524	tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity	IEA	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0006400	tRNA modification	TAS	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881