• Gene id: 128646

Gene Summary

• Gene Symbol: SIRPD   Gene   UCSC   Ensembl
• Aliases: PTPNS1L2, dJ576H24.4
• Gene name: signal regulatory protein delta
• Alternate names: signal-regulatory protein delta, SIRP-delta, protein tyrosine phosphatase, non-receptor type substrate 1-like 2,
• Gene location: 20p13 (1557704: 1534250)     Exons: 4     NC_000020.11

Protein Summary

• Protein general information: Q9H106  
  • Name: Signal regulatory protein delta (SIRP delta) (Protein tyrosine phosphatase non receptor type substrate 1 like 2)
  • Length: 197  
  • Mass: 21687
• Sequence:

  MPIPASPLHPPLPSLLLYLLLELAGVTHVFHVQQTEMSQTVSTGESIILSCSVPNTLPNGPVLWFKGTGPNRKLI
  YNFKQGNFPRVKEIGDTTKPGNTDFSTRIREISLADAGTYYCVKFIKGRAIKEYQSGRGTQVFVTEQNPRPPKNR
  PAGRAGSRAHHDAHTCLSALPERNSTNYFVQPCCCLRLLGLTGLLSK

• Structural information:
  • Protein Domains: (31..13-)
    (/note="Ig-like-V-type")
  • Interpro: IPR007110  IPR036179  IPR013783  IPR003599  IPR013106  
  • Prosite: PS50835
  • STRING: ENSP00000371036
• Other Databases: GeneCards:  SIRPD  Malacards:  SIRPD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IBA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)