• Gene id: 128229

Gene Summary

• Gene Symbol: TSACC   Gene   UCSC   Ensembl
• Aliases: C1orf182, SIP, SSTK-IP
• Gene name: TSSK6 activating cochaperone
• Alternate names: TSSK6-activating co-chaperone protein, SSTK-interacting protein (SSTK-IP), TSSK6 activating co-chaperone,
• Gene location: 1q22 (156337313: 156346994)     Exons: 6     NC_000001.11

Protein Summary

• Protein general information: Q96A04  
  • Name: TSSK6 activating co chaperone protein (SSTK interacting protein) (SSTK IP)
  • Length: 125  
  • Mass: 13670
  • Tissue specificity: Expressed in testis but is absent from mature sperm. {ECO
• Sequence:

  MERHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATFLNIQTTKLPSVDHKPKECLGLLECMYANLQL
  QTQLAQQQMAVLEHLQASVTQLAPGRGSNNSSLPALSPNPLLNHLPQFSK

• Structural information:
  • Interpro: IPR031679  
  • STRING: ENSP00000357238
• Other Databases: GeneCards:  TSACC  Malacards:  TSACC

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051087	chaperone binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0051087	chaperone binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051087	chaperone binding	IPI	molecular function

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray