• Gene id: 127829

Gene Summary

• Gene Symbol: ARL8A   Gene   UCSC   Ensembl
• Aliases: ARL10B, GIE2
• Gene name: ADP ribosylation factor like GTPase 8A
• Alternate names: ADP-ribosylation factor-like protein 8A, ADP-ribosylation factor-like 10B, ADP-ribosylation factor-like 8A, novel small G protein indispensable for equal chromosome segregation 2,
• Gene location: 1q32.1 (202144742: 202133403)     Exons: 7     NC_000001.11
• OMIM: 616024

Protein Summary

• Protein general information: Q96BM9  
  • Name: ADP ribosylation factor like protein 8A (ADP ribosylation factor like protein 10B) (Novel small G protein indispensable for equal chromosome segregation 2)
  • Length: 186  
  • Mass: 21416
  • Tissue specificity: Ubiquitously expressed. {ECO
• Sequence:

  MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQ
  PRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQLQGIPVLVLGNKRDLPGALDEKELIEKMNLS
  AIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS

• Structural information:
  • Interpro: IPR027417  IPR005225  IPR006689  
  • Prosite: PS51417
  • PDB: 1ZD9 2H18 4ILE
  • PDBsum: 1ZD9 2H18 4ILE
  • STRING: ENSP00000272217
• Other Databases: GeneCards:  ARL8A  Malacards:  ARL8A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005765	lysosomal membrane	IBA	cellular component
GO:0005774	vacuolar membrane	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005525	GTP binding	IEA	molecular function
GO:0051301	cell division	IEA	biological process
GO:0015031	protein transport	IEA	biological process
GO:0007059	chromosome segregation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0007049	cell cycle	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0035577	azurophil granule membrane	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0101003	ficolin-1-rich granule membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008089	anterograde axonal transport	IEA	biological process
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0031902	late endosome membrane	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005819	spindle	IEA	cellular component
GO:1904115	axon cytoplasm	IEA	cellular component
GO:0051233	spindle midzone	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005525	GTP binding	IDA	molecular function
GO:0007059	chromosome segregation	ISS	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005765	lysosomal membrane	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0048487	beta-tubulin binding	ISS	molecular function
GO:0043014	alpha-tubulin binding	ISS	molecular function
GO:0003924	GTPase activity	NAS	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)