• Gene id: 127294

Gene Summary

• Gene Symbol: MYOM3   Gene   UCSC   Ensembl
• Gene name: myomesin 3
• Alternate names: myomesin-3, myomesin family, member 3,
• Gene location: 1p36.11 (24112134: 24056040)     Exons: 37     NC_000001.11
• OMIM: 616832

Protein Summary

• Protein general information: Q5VTT5  
  • Name: Myomesin 3 (Myomesin family member 3)
  • Length: 1437  
  • Mass: 162189
• Sequence:

  MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGSSVRRRTFRSSEEEHEFSAADYALAAALALTA
  SSELSWEAQLRRQTSAVELEERGQKRVGFGNDWERTEIAFLQTHRLLRQRRDWKTLRRRTEEKVQEAKELRELCY
  GRGPWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDS
  ATYTVRVKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLD
  AESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYVLVRDAEAENPGAPGS
  PLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAI
  SRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPS
  PRDRAPLTYSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPA
  TLPPPAQVQAFRDTQTSVSLTWDPVKDPELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRS
  VSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVN
  QQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLVLQWEPP
  LYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLLEDKP
  GAHEIEVGVDEEGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKVILKEPGLEDLGTYSVIVTD
  ADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDILERGEVRLWLEVEKLSPAAELHLIFNNKEIFSSP
  NRKINFDREKGLVEVIIQNLSEEDKGSYTAQLQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERP
  LQWKVTEDCQVQLTCKVTNTKKETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSDDRGEDDT
  ILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDE
  IWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIMEDK
  TLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVF
  KHGDEPKELKSM

• Structural information:
  • Protein Domains: (154..24-)
    1 (/note="Ig-like-C2-type)
    (269..36-)
    2 (/note="Ig-like-C2-type)
    (375..46-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (503..59-)
    2 (/note="Fibronectin-type-III)
    (/evidence="EC-)
  • Interpro: IPR003961  IPR036116  IPR007110  IPR036179  IPR013783   IPR013098  IPR003599  IPR003598  IPR013151  
  • Prosite: PS50853 PS50835
  • CDD: cd00063
  • STRING: ENSP00000363557
• Other Databases: GeneCards:  MYOM3  Malacards:  MYOM3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0055008	cardiac muscle tissue morphogenesis	IBA	biological process
GO:0055003	cardiac myofibril assembly	IBA	biological process
GO:0051015	actin filament binding	IBA	molecular function
GO:0030241	skeletal muscle myosin thick filament assembly	IBA	biological process
GO:0030240	skeletal muscle thin filament assembly	IBA	biological process
GO:0008307	structural constituent of muscle	IBA	molecular function
GO:0007015	actin filament organization	IBA	biological process
GO:0005865	striated muscle thin filament	IBA	cellular component
GO:0071688	striated muscle myosin thick filament assembly	IBA	biological process
GO:0051371	muscle alpha-actinin binding	IBA	molecular function
GO:0048739	cardiac muscle fiber development	IBA	biological process
GO:0045214	sarcomere organization	IBA	biological process
GO:0031430	M band	IBA	cellular component
GO:0030018	Z disc	IBA	cellular component
GO:0030017	sarcomere	IBA	cellular component
GO:0006941	striated muscle contraction	IBA	biological process
GO:0006936	muscle contraction	IBA	biological process
GO:0042803	protein homodimerization activity	ISS	molecular function
GO:0031430	M band	ISS	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0042803	protein homodimerization activity	IEA	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0031430	M band	IEA	cellular component
GO:0031430	M band	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)