• Gene id: 127018

Gene Summary

• Gene Symbol: LYPLAL1   Gene   UCSC   Ensembl
• Aliases: Q96AV0
• Gene name: lysophospholipase like 1
• Alternate names: lysophospholipase-like protein 1,
• Gene location: 1q41 (219173830: 219445120)     Exons: 19     NC_000001.11
• OMIM: 616548

Protein Summary

• Protein general information: Q5VWZ2  
  • Name: Lysophospholipase like protein 1 (EC 3.1.2. )
  • Length: 237  
  • Mass: 26316
• Sequence:

  MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISN
  VWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSF
  LNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWI
  LTKLPGEMEKQK

• Structural information:
  • Interpro: IPR029058  IPR003140  
  • PDB: 3U0V 5KRE
  • PDBsum: 3U0V 5KRE
  • STRING: ENSP00000355895
• Other Databases: GeneCards:  LYPLAL1  Malacards:  LYPLAL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002084	protein depalmitoylation	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0008474	palmitoyl-(protein) hydrolase activity	IBA	molecular function
GO:0052689	carboxylic ester hydrolase activity	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005829	cytosol	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0004622	lysophospholipase activity	NAS	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881