• Gene id: 125476

Gene Summary

• Gene Symbol: INO80C   Gene   UCSC   Ensembl
• Aliases: C18orf37, IES6, hIes6
• Gene name: INO80 complex subunit C
• Alternate names: INO80 complex subunit C, IES6 homolog,
• Gene location: 18q12.2 (35497959: 35468332)     Exons: 9     NC_000018.10

Protein Summary

• Protein general information: Q6PI98  
  • Name: INO80 complex subunit C (IES6 homolog) (hIes6)
  • Length: 192  
  • Mass: 20643
• Sequence:

  MAAQIPIVATTSTPGIVRNSKKRPASPSHNGSSGGGYGASKKKKASASSFAQGISMEAMSENKMVPSEFSTGPVE
  KAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLA
  NYTDPQSKLRFSTIEEFSYIRRLPSDVVTGYLALRKATSIVP

• Structural information:
  • Interpro: IPR029525  IPR013272  
  • STRING: ENSP00000467041
• Other Databases: GeneCards:  INO80C  Malacards:  INO80C

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031011	Ino80 complex	IBA	cellular component
GO:0006338	chromatin remodeling	IBA	biological process
GO:0071339	MLL1 complex	IDA	cellular component
GO:0031011	Ino80 complex	IDA	cellular component
GO:0006338	chromatin remodeling	IEA	biological process
GO:0031011	Ino80 complex	IEA	cellular component
GO:0006281	DNA repair	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006310	DNA recombination	IEA	biological process
GO:0016579	protein deubiquitination	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R