• Gene id: 124995

Gene Summary

• Gene Symbol: MRPL10   Gene   UCSC   Ensembl
• Aliases: L10MT, MRP-L10, MRP-L8, MRPL8, RPML8
• Gene name: mitochondrial ribosomal protein L10
• Alternate names: 39S ribosomal protein L10, mitochondrial, 39S ribosomal protein L8, mitochondrial, L8mt, mitochondrial large ribosomal subunit protein uL10m,
• Gene location: 17q21.32 (17281302: 17246615)     Exons: 13     NC_000017.11
• Gene summary(Entrez): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot
• OMIM: 611825

Protein Summary

• Protein general information: Q7Z7H8  
  • Name: 39S ribosomal protein L10, mitochondrial (L10mt) (MRP L10) (39S ribosomal protein L8, mitochondrial) (L8mt) (MRP L8) (Mitochondrial large ribosomal subunit protein uL10m)
  • Length: 261  
  • Mass: 29283
• Sequence:

  MAAAVAGMLRGGLLPQAGRLPTLQTVRYGSKAVTRHRRVMHFQRQKLMAVTEYIPPKPAIHPSCLPSPPSPPQEE
  IGLIRLLRREIAAVFQDNRMIAVCQNVALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSKYQNLLPLFVGH
  NMLLVSEEPKVKEMVRILRTVPFLPLLGGCIDDTILSRQGFINYSKLPSLPLVQGELVGGLTCLTAQTHSLLQHQ
  PLQLTTLLDQYIREQREKDSVMSANGKPDPDTVPDS

• Structural information:
  • Interpro: IPR001790  
  • CDD: cd05797
  • PDB: 3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
  • PDBsum: 3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
  • DIP: 59717
  • STRING: ENSP00000290208
• Other Databases: GeneCards:  MRPL10  Malacards:  MRPL10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006412	translation	IBA	biological process
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0005762	mitochondrial large ribosomal subunit	IBA	cellular component
GO:0015934	large ribosomal subunit	IBA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0042254	ribosome biogenesis	IEA	biological process
GO:0005840	ribosome	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0070125	mitochondrial translational elongation	TAS	biological process
GO:0070126	mitochondrial translational termination	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003735	structural constituent of ribosome	ISS	molecular function
GO:1990904	ribonucleoprotein complex	ISS	cellular component
GO:0005762	mitochondrial large ribosomal subunit	ISS	cellular component
GO:0006412	translation	ISS	biological process

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881