• Gene id: 124912

Gene Summary

• Gene Symbol: SPACA3   Gene   UCSC   Ensembl
• Aliases: ALLP17, CT54, LYC3, LYZC, LYZL3, SLLP1
• Gene name: sperm acrosome associated 3
• Alternate names: sperm acrosome membrane-associated protein 3, cancer/testis antigen 54, lysozyme C, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, lysozyme-like protein 3, lysozyme-like sperm-specific secretory protein ALLP17, sperm lysozyme-like prote,
• Gene location: 17q11.2 (32991863: 32997876)     Exons: 6     NC_000017.11
• Gene summary(Entrez): The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal ac
• OMIM: 612749

Protein Summary

• Protein general information: Q8IXA5  
  • Name: Sperm acrosome membrane associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme like acrosomal sperm specific secretory protein ALLP 17) (Lysozyme like protein 3) (Sperm lysozyme like protein 1) (Sperm protein reactive with antisperm antibodies)
  • Length: 215  
  • Mass: 23,431
• Sequence:

  MVSALRGAPLIRVHSSPVSSPSVSGPRRLVSCLSSQSSALSQSGGGSTSAAGIEARSRALRRRWCPAGIMLLALV
  CLLSCLLPSSEAKLYGRCELARVLHDFGLDGYRGYSLADWVCLAYFTSGFNAAALDYEADGSTNNGIFQINSRRW
  CSNLTPNVPNVCRMYCSDLLNPNLKDTVICAMKITQEPQGLGYWEAWRHHCQGKDLTEWVDGCDF

• Structural information:
  • Interpro: IPR001916  IPR019799  IPR000974  IPR023346  IPR030058  
  • Prosite: PS00128 PS51348
  • CDD: cd00119
  • STRING: ENSP00000269053
• Other Databases: GeneCards:  SPACA3  Malacards:  SPACA3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002080	acrosomal membrane	IEA	cellular component
GO:0003796	lysozyme activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005764	lysosome	IDA	cellular component
GO:0009253	peptidoglycan catabolic process	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016998	cell wall macromolecule catabolic process	TAS	biological process
GO:0030141	secretory granule	IDA	cellular component
GO:0035036	sperm-egg recognition	IEA	biological process
GO:0042117	monocyte activation	TAS	biological process
GO:0043032	positive regulation of macrophage activation	TAS	biological process
GO:0050766	positive regulation of phagocytosis	TAS	biological process
GO:0050830	defense response to Gram-positive bacterium	TAS	biological process
GO:0001669	acrosomal vesicle	IEA	cellular component
GO:0002080	acrosomal membrane	IEA	cellular component
GO:0003796	lysozyme activity	IEA	molecular function
GO:0003796	lysozyme activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005764	lysosome	IDA	cellular component
GO:0009253	peptidoglycan catabolic process	TAS	biological process
GO:0009566	fertilization	IEA	biological process
GO:0009615	response to virus	TAS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016998	cell wall macromolecule catabolic process	TAS	biological process
GO:0030141	secretory granule	IDA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0035036	sperm-egg recognition	IEA	biological process
GO:0042117	monocyte activation	TAS	biological process
GO:0043032	positive regulation of macrophage activation	TAS	biological process
GO:0050766	positive regulation of phagocytosis	TAS	biological process
GO:0050830	defense response to Gram-positive bacterium	TAS	biological process
GO:0003796	lysozyme activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005764	lysosome	IDA	cellular component
GO:0009253	peptidoglycan catabolic process	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0016998	cell wall macromolecule catabolic process	TAS	biological process
GO:0030141	secretory granule	IDA	cellular component
GO:0042117	monocyte activation	TAS	biological process
GO:0043032	positive regulation of macrophage activation	TAS	biological process
GO:0050766	positive regulation of phagocytosis	TAS	biological process
GO:0050830	defense response to Gram-positive bacterium	TAS	biological process

Diseases

Associated diseases	References
Female infertility	INFBASE: 25038051
Male factor infertility	MIK: 24872021
Immunoinfertility	MIK: 14747161
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Immune-mediated infertility	MIK: 14747161
Male infertility	MIK: 24872021
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24872021	Male infertility	insertion of TGC within a quadruple tri-nucleotide (TGC) repeat region in the 5' untranslated region (UTR) (g.-22TGC(4_5), guanine to adenosine transition at position 239 (c.239G>A) resulting in a non-synonymous amino acid substitution from cysteine to ty		206 (102 infertile couples, 104 fertile couples)	Male infertility, Female infertility
14747161	Immune-mediated infertility				Male infertility	SPRASA
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray