• Gene id: 123283

Gene Summary

• Gene Symbol: TARS3   Gene   UCSC   Ensembl
• Aliases: TARSL2, ThrRS-L
• Gene name: threonyl-tRNA synthetase 3
• Alternate names: threonine--tRNA ligase 2, cytoplasmic, probable threonine--tRNA ligase 2, cytoplasmic, probable threonyl-tRNA synthetase 2, cytoplasmic, thrRS, threonine--tRNA ligase, threonyl-tRNA synthetase like 2, threonyl-tRNA synthetase protein 3, threonyl-tRNA synthetase-,
• Gene location: 15q26.3 (101724472: 101653595)     Exons: 22     NC_000015.10
• OMIM: 173461

Protein Summary

• Protein general information: A2RTX5  
  • Name: Threonine tRNA ligase 2, cytoplasmic (EC 6.1.1.3) (Threonyl tRNA synthetase) (ThrRS) (Threonyl tRNA synthetase protein 3)
  • Length: 802  
  • Mass: 92646
• Sequence:

  MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQAEGPCLTREVAQLRAENCDLRHRLCSLRLCL
  AEERSRQATLESAELEAAQEAGAQPPPSQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLA
  IYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDN
  EEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEV
  SKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQR
  IYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTE
  VLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELS
  GTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQN
  SLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGS
  VERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKKIRNAQLAQYN
  FILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRKTRTLNAEEAF

• Structural information:
  • Protein Domains: (157..22-)
    (/note="TGS-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01228"-)
  • Interpro: IPR002314  IPR006195  IPR004154  IPR036621  IPR012675   IPR004095  IPR012676  IPR002320  IPR018163  IPR033728  IPR012947  
  • Prosite: PS50862 PS51880
  • CDD: cd00771
  • STRING: ENSP00000338093
• Other Databases: GeneCards:  TARS3  Malacards:  TARS3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004812	aminoacyl-tRNA ligase activity	IBA	molecular function
GO:0004829	threonine-tRNA ligase activity	IBA	molecular function
GO:0006418	tRNA aminoacylation for protein translation	IBA	biological process
GO:0006435	threonyl-tRNA aminoacylation	IBA	biological process
GO:0004812	aminoacyl-tRNA ligase activity	IEA	molecular function
GO:0004829	threonine-tRNA ligase activity	IEA	molecular function
GO:0006418	tRNA aminoacylation for protein translation	IEA	biological process
GO:0043039	tRNA aminoacylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006435	threonyl-tRNA aminoacylation	IEA	biological process
GO:0006412	translation	IEA	biological process
GO:0004812	aminoacyl-tRNA ligase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016874	ligase activity	IEA	molecular function
GO:0004829	threonine-tRNA ligase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0004829	threonine-tRNA ligase activity	IEA	molecular function
GO:0006435	threonyl-tRNA aminoacylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008150	biological_process	ND	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005575	cellular_component	ND	cellular component
GO:0003674	molecular_function	ND	molecular function
GO:0005737	cytoplasm	ISS	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0006435	threonyl-tRNA aminoacylation	ISS	biological process
GO:0004829	threonine-tRNA ligase activity	ISS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa00970	Aminoacyl-tRNA biosynthesis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881