• Gene id: 122651

Gene Summary

• Gene Symbol: RNASE11   Gene   UCSC   Ensembl
• Aliases: C14orf6, HEL-S-84p, RAJ1
• Gene name: ribonuclease A family member 11 (inactive)
• Alternate names: probable ribonuclease 11, RNase 11, epididymis secretory sperm binding protein Li 84p, ribonuclease 11, ribonuclease A J1, ribonuclease, RNase A family, 11 (non-active),
• Gene location: 14q11.2 (20590257: 20582891)     Exons: 3     NC_000014.9

Protein Summary

• Protein general information: Q8TAA1  
  • Name: Probable ribonuclease 11 (RNase 11) (EC 3.1.27. )
  • Length: 199  
  • Mass: 22427
• Sequence:

  METFPLLLLSLGLVLAEASESTMKIIKEEFTDEEMQYDMAKSGQEKQTIEILMNPILLVKNTSLSMSKDDMSSTL
  LTFRSLHYNDPKGNSSGNDKECCNDMTVWRKVSEANGSCKWSNNFIRSSTEVMRRVHRAPSCKFVQNPGISCCES
  LELENTVCQFTTGKQFPRCQYHSVTSLEKILTVLTGHSLMSWLVCGSKL

• Structural information:
  • Interpro: IPR029743  IPR001427  IPR036816  IPR023412  
  • STRING: ENSP00000476537
• Other Databases: GeneCards:  RNASE11  Malacards:  RNASE11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004540	ribonuclease activity	IBA	NOT|molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0004519	endonuclease activity	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0004540	ribonuclease activity	IKR	NOT|molecular function
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray