• Gene id: 122402

Gene Summary

• Gene Symbol: TDRD9   Gene   UCSC   Ensembl
• Aliases: C14orf75, HIG-1, NET54
• Gene name: tudor domain containing 9
• Alternate names: ATP-dependent RNA helicase TDRD9, hypoxia-inducible HIG-1, putative ATP-dependent RNA helicase TDRD9, tudor domain-containing protein 9,
• Gene location: 14q32.33 (103928342: 104052666)     Exons: 39     NC_000014.9
• OMIM: 0

Protein Summary

• Protein general information: Q8NDG6  
  • Name: ATP dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain containing protein 9)
  • Length: 1382  
  • Mass: 155,683
• Sequence:

  MLRKLTIEQINDWFTIGKTVTNVELLGAPPAFPAGAAREEVQRQDVAPGAGPAAQAPALAQAPARPAAAFERSLS
  QRSSEVEYINKYRQLEAQELDVCRSVQPTSGPGPRPSLAKLSSVTCIPGTTYKYPDLPISRYKEEVVSLIESNSV
  VIIHGATGSGKSTQLPQYILDHYVQRSAYCSIVVTQPRKIGASSIARWISKERAWTLGGVVGYQVGLEKIATEDT
  RLIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFA
  VPVQNKMNPAYIFEVEGKPHSVEEYYLNDLEHIHHSKLSPHLLEEPVITKDIYEVAVSLIQMFDDLDMKESGNKA
  WSGAQFVLERSSVLVFLPGLGEINYMHELLTSLVHKRLQVYPLHSSVALEEQNNVFLSPVPGYRKIILSTNIAES
  SVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQRKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPE
  MLRCPLGSTILKVKLLDMGEPRALLATALSPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQ
  LPVNQQLGKLIVLGHVFGCLDECLIIAAALSLKNFFAMPFRQHLDGYRNKVNFSGSSKSDCIALVEAFKTWKACR
  QTGELRYPKDELNWGRLNYIQIKRIREVAELYEELKTRISQFNMHVDSRRPVMDQEYIYKQRFILQVVLAGAFYP
  NYFTFGQPDEEMAVRELAGKDPKTTVVLKHIPPYGFLYYKQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFK
  TLPAVYMAIKMSQLKVSLELSVHSAEEIEGKVQGMNVSKLRNTRVNVDFQKQTVDPMQVSFNTSDRSQTVTDLLL
  TIDVTEVVEVGHFWGYRIDENNSEILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADFDKQRYFRAQVLYVSGNS
  AEVFFVDYGNKSHVDLHLLMEIPCQFLELPFQALEFKICKMRPSAKSLVCGKHWSDGASQWFASLVSGCTLLVKV
  FSVVHSVLHVDVYQYSGVQDAINIRDVLIQQGYAELTEESYESKQSHEVLKGLFSKSVENMTDGSVPFPMKDDEK
  YLIRILLESFSTNKLGTPNCKAELHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDAPEDLHQRMLVAAS
  LSINATGSTMLLRETSLMPHIPGLPALLSMLFAPVIELRIDQNGKYYTGVLCGLGWNPATGASILPEHDMELAFD
  VQFSVEDVVEVNILRAAINKLVCDGPNGCKCLGPERVAQLQDIARQKLLGLFCQSKPREKIVPKWHEKPYEWNQV
  DPKLVMEQADRESSRGKNTFLYQLHKLVVLGT

• Structural information:
  • Protein Domains: Helicase (142-308)
    Helicase (377-544)
    Tudor. (944-1004)
  • Interpro: IPR011545  IPR007502  IPR014001  IPR001650  IPR027417   IPR035437  IPR002999  
  • Prosite: PS51192 PS51194 PS50304
  • CDD: cd00079
  • STRING: ENSP00000387303
• Other Databases: GeneCards:  TDRD9  Malacards:  TDRD9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004004	ATP-dependent RNA helicase activity	IBA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	ISS	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0006396	RNA processing	IBA	biological process
GO:0007140	male meiosis	ISS	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0009566	fertilization	ISS	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0031047	gene silencing by RNA	IEA	biological process
GO:0034587	piRNA metabolic process	ISS	biological process
GO:0043046	DNA methylation involved in gamete generation	ISS	biological process
GO:0043186	P granule	IBA	cellular component
GO:0044822	poly(A) RNA binding	IBA	molecular function
GO:0071547	piP-body	ISS	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0004004	ATP-dependent RNA helicase activity	IBA	molecular function
GO:0004386	helicase activity	IEA	molecular function
GO:0004386	helicase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0006396	RNA processing	IBA	biological process
GO:0007140	male meiosis	IEA	biological process
GO:0007140	male meiosis	ISS	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0009566	fertilization	IEA	biological process
GO:0009566	fertilization	ISS	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0030154	cell differentiation	IEA	biological process
GO:0031047	gene silencing by RNA	IEA	biological process
GO:0034587	piRNA metabolic process	IEA	biological process
GO:0034587	piRNA metabolic process	ISS	biological process
GO:0043046	DNA methylation involved in gamete generation	IEA	biological process
GO:0043046	DNA methylation involved in gamete generation	ISS	biological process
GO:0043186	P granule	IBA	cellular component
GO:0044822	poly(A) RNA binding	IBA	molecular function
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0071547	piP-body	IEA	cellular component
GO:0071547	piP-body	ISS	cellular component
GO:0004004	ATP-dependent RNA helicase activity	IBA	molecular function
GO:0005634	nucleus	ISS	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0006396	RNA processing	IBA	biological process
GO:0007140	male meiosis	ISS	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0009566	fertilization	ISS	biological process
GO:0034587	piRNA metabolic process	ISS	biological process
GO:0043046	DNA methylation involved in gamete generation	ISS	biological process
GO:0043186	P granule	IBA	cellular component
GO:0044822	poly(A) RNA binding	IBA	molecular function
GO:0071547	piP-body	ISS	cellular component

Diseases

Associated diseases	References
Arthritis	GAD: 20549515
Bipolar disorder	GAD: 19308021
Cryptorchidism	MIK: 22223142
Cryptorchidism	MIK: 22223142
Non-obstructive azoospermia	MIK: 28536242
Cryptozoospermia	MIK: 28536242
Male infertility	MIK: 28536242
Sperm number defects	MIK: 29713536
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
22223142	Cryptorchidism			22 (18 cryptorchid, 4 control testes)	Male infertility	TDRD9
29713536	Sperm number defects	c.720_723 del TAGT (p.Ser241Profs*4)			Male infertility	NGS
28536242	Non-obstructive azoospermia, cryptozoospermia, Male infertility	c.720_723 del TAGT causing p.Ser241Pro fs Ter 4	Bedouin	238 (5 cases, 233 controls)	Male infertility	NGS
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray