• Gene id: 120406

Gene Summary

• Gene Symbol: NXPE2   Gene   UCSC   Ensembl
• Aliases: FAM55B
• Gene name: neurexophilin and PC-esterase domain family member 2
• Alternate names: NXPE family member 2, family with sequence similarity 55, member B, protein FAM55B,
• Gene location: 11q23.2-q23.3 (114587768: 114598878)     Exons: 3     NC_000009.12

Protein Summary

• Protein general information: Q96DL1  
  • Name: NXPE family member 2 (Protein FAM55B)
  • Length: 559  
  • Mass: 64901
• Sequence:

  MVEKILIHRILTLFPNAIARKLLLMLTFILIFWIIYLASKDHTKFSFNLENHIILNQGNIFKKYSHSETPLCPAV
  SPKETELRIKDIMEKLDQQIPPRPFTHVNTTTSATHSTATILNPQDTYCRGDQLDILLEVRDHLGHRKQYGGDFL
  RARMYSTALMAGASGKVTDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGVSALWRARNQGCDRIIFTGLFANRSS
  NVFTECGLTLNTNAELCQYMDDRDQEAFYCVRPQHMPCEALTHMTTRTRNISYLSKEEWRLFHRSNIGVEMMKNF
  TPIEVIPCNKSENIKKNCQIGMKTPFPSGYTLKKMWITAFCKQIKFNETKNINDCLERKLIYLMGDSTLHQWIYY
  LQKAVKTLKYFDHHGAGIFKTHVLLDVERHILIQWKKHGHPFVTKKLFSVKDENYIPREIDQVAGDKNTAIVITL
  GQHFRPFPINIFIRRAINIQKAIERLFLRSPETKVILKTENTREIEQNAEMFSDFHGYIQNLIIRDIFVDLNVGI
  IDAWDMTIAYCTNNAHPPDYVIQNQIGMFLNYIC

• Structural information:
  • Interpro: IPR013783  IPR014756  IPR026845  
  • STRING: ENSP00000374237
• Other Databases: GeneCards:  NXPE2  Malacards:  NXPE2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)