• Gene id: 119016

Gene Summary

• Gene Symbol: AGAP4   Gene   UCSC   Ensembl
• Aliases: AGAP-4, AGAP-8, AGAP8, CTGLF1, CTGLF5, MRIP2
• Gene name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
• Alternate names: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4, ARF GTPase-activating protein, ArfGAP with GTPase domain, ankyrin repeat and PH domain 8, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 8, centaurin, gamma-like family, mem,
• Gene location: 10q11.22 (45853876: 45825591)     Exons: 11     NC_000010.11

Protein Summary

• Protein general information: Q96P64  
  • Name: Arf GAP with GTPase, ANK repeat and PH domain containing protein 4 (AGAP 4) (Centaurin gamma like family member 1) (Centaurin gamma like family member 5)
  • Length: 663  
  • Mass: 73070
• Sequence:

  MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGEDLHMHHVRDREMPEA
  LEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPH
  HITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSM
  RWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
  KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHAN
  KKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNM
  RGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSS
  QGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD
  GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDKCV

• Structural information:
  • Protein Domains: (259..42-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (441..56-)
    (/note="Arf-GAP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00288"-)
  • Interpro: IPR002110  IPR020683  IPR036770  IPR037278  IPR001164   IPR038508  IPR001849  
  • Prosite: PS50297 PS50088 PS50115 PS50003
  • STRING: ENSP00000392513
• Other Databases: GeneCards:  AGAP4  Malacards:  AGAP4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005096	GTPase activator activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005096	GTPase activator activity	IEA	molecular function
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0043547	positive regulation of GTPase activity	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04144	Endocytosis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881