• Gene id: 118611

Gene Summary

• Gene Symbol: C10orf90   Gene   UCSC   Ensembl
• Aliases: FATS, bA422P15.2
• Gene name: chromosome 10 open reading frame 90
• Alternate names: (E2-independent) E3 ubiquitin-conjugating enzyme FATS, E2/E3 hybrid ubiquitin-protein ligase FATS, centrosomal protein C10orf90, fragile-site associated tumor suppressor homolog,
• Gene location: 10q26.2 (23069030: 23020132)     Exons: 10     NC_000008.11
• OMIM: 617735

Protein Summary

• Protein general information: Q96M02  
  • Name: (E2 independent) E3 ubiquitin conjugating enzyme FATS (EC 2.3.2. ) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin protein ligase FATS) (Fragile site associated tumor suppressor homolog) (FATS)
  • Length: 699  
  • Mass: 77910
• Sequence:

  MLKLSGEGLRDSYHSRRDQIALKNLQSDVTEAKSDFTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCA
  IAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPKEERPCGGPRRGFASITITARRVGPP
  ARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVT
  HADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHR
  LTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELAN
  VGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLP
  IGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKE
  CKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFISRSQERLKKLEHMVQQ
  RKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVIL
  QSNRLRAEVFKKQLLDQLLQRNAV

• Structural information:
  • Interpro: IPR029299  IPR041179  IPR029561  
  • STRING: ENSP00000284694
• Other Databases: GeneCards:  C10orf90  Malacards:  C10orf90

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0046599	regulation of centriole replication	IBA	biological process
GO:0008017	microtubule binding	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0005813	centrosome	IBA	cellular component
GO:0005814	centriole	IBA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0015629	actin cytoskeleton	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0061630	ubiquitin protein ligase activity	ISS	molecular function
GO:0050821	protein stabilization	ISS	biological process
GO:0016567	protein ubiquitination	ISS	biological process
GO:0000209	protein polyubiquitination	ISS	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq