• Gene id: 115708

Gene Summary

• Gene Symbol: TRMT61A   Gene   UCSC   Ensembl
• Aliases: C14orf172, GCD14, Gcd14p, TRM61, hTRM61
• Gene name: tRNA methyltransferase 61A
• Alternate names: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A, tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61, tRNA (adenine-N(1)-)-methyltransferase catalytic subun,
• Gene location: 14q32.33 (118342324: 118297924)     Exons: 11     NC_000010.11

Protein Summary

• Protein general information: Q96FX7  
  • Name: tRNA (adenine(58) N(1)) methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine N(1) methyltransferase catalytic subunit TRMT61A) (EC 2.1.1. ) (tRNA(m1A58) methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A)
  • Length: 289  
  • Mass: 31382
• Sequence:

  MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCGRGGWVYVLHPTPEL
  WTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQE
  HRVGRWVTVRTQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGF
  SELSTLEVLPQVYNVRTVSLPPPDLGTGTDGPAGSDTSPFRSGTPMKEAVGHTGYLTFATKTPG

• Structural information:
  • Interpro: IPR029063  IPR014816  
  • Prosite: PS51620
  • PDB: 5CCB 5CCX 5CD1
  • PDBsum: 5CCB 5CCX 5CD1
  • STRING: ENSP00000374399
• Other Databases: GeneCards:  TRMT61A  Malacards:  TRMT61A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031515	tRNA (m1A) methyltransferase complex	IBA	cellular component
GO:0030488	tRNA methylation	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0061953	mRNA (adenine-N1-)-methyltransferase activity	IDA	molecular function
GO:0061953	mRNA (adenine-N1-)-methyltransferase activity	IDA	molecular function
GO:0080009	mRNA methylation	IDA	biological process
GO:0080009	mRNA methylation	IDA	biological process
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	IEA	molecular function
GO:0030488	tRNA methylation	IEA	biological process
GO:0031515	tRNA (m1A) methyltransferase complex	IEA	cellular component
GO:0032259	methylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0006400	tRNA modification	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq