• Gene id: 1155

Gene Summary

• Gene Symbol: TBCB   Gene   UCSC   Ensembl
• Aliases: CG22, CKAP1, CKAPI
• Gene name: tubulin folding cofactor B
• Alternate names: tubulin-folding cofactor B, cytoskeleton associated protein 1, cytoskeleton-associated protein CKAPI, tubulin-specific chaperone B,
• Gene location: 19q13.12 (36114985: 36125947)     Exons: 7     NC_000019.10
• OMIM: 601303

Protein Summary

• Protein general information: Q99426  
  • Name: Tubulin folding cofactor B (Cytoskeleton associated protein 1) (Cytoskeleton associated protein CKAPI) (Tubulin specific chaperone B)
  • Length: 244  
  • Mass: 27326
  • Tissue specificity: Found in most tissues.
• Sequence:

  MEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKCKLELLVGSPASCMELELYGVDDKFYSKLDQEDALLG
  SYPVDDGCRIHVIDHSGARLGEYEDVSRVEKYTISQEAYDQRQDTVRSFLKRSKLGRYNEEERAQQEAEAAQRLA
  EEKAQASSIPVGSRCEVRAAGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVK
  PAVVTVGDFPEEDYGLDEI

• Structural information:
  • Protein Domains: (183..22-)
    (/note="CAP-Gly-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00045"-)
  • Interpro: IPR036859  IPR000938  IPR000626  IPR029071  
  • Prosite: PS00845 PS50245
  • DIP: 34409
  • STRING: ENSP00000221855
• Other Databases: GeneCards:  TBCB  Malacards:  TBCB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031122	cytoplasmic microtubule organization	IBA	biological process
GO:0030424	axon	IBA	cellular component
GO:0007097	nuclear migration	IBA	biological process
GO:0005938	cell cortex	IBA	cellular component
GO:0000776	kinetochore	IBA	cellular component
GO:0000132	establishment of mitotic spindle orientation	IBA	biological process
GO:0051010	microtubule plus-end binding	IBA	molecular function
GO:0035371	microtubule plus-end	IBA	cellular component
GO:0005875	microtubule associated complex	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0000922	spindle pole	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0030154	cell differentiation	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0015630	microtubule cytoskeleton	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq