• Gene id: 115330

Gene Summary

• Gene Symbol: GPR146   Gene   UCSC   Ensembl
• Aliases: PGR8
• Gene name: G protein-coupled receptor 146
• Alternate names: probable G-protein coupled receptor 146, G-protein coupled receptor PGR8,
• Gene location: 7p22.3 (1044545: 1059260)     Exons: 4     NC_000007.14

Protein Summary

• Protein general information: Q96CH1  
  • Name: Probable G protein coupled receptor 146 (G protein coupled receptor PGR8)
  • Length: 333  
  • Mass: 36580
• Sequence:

  MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLV
  LSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGF
  VWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTG
  RLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMN
  QSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA

• Structural information:
  • Interpro: IPR000276  IPR017452  IPR037487  
  • Prosite: PS50262
  • STRING: ENSP00000380283
• Other Databases: GeneCards:  GPR146  Malacards:  GPR146

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IDA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R