• Gene id: 113802

Gene Summary

• Gene Symbol: HENMT1   Gene   UCSC   Ensembl
• Aliases: C1orf59, HEN1
• Gene name: HEN methyltransferase 1
• Alternate names: small RNA 2'-O-methyltransferase, HEN1 methyltransferase homolog 1, hua enhancer 1 homolog 1,
• Gene location: 1p13.3 (108661525: 108648287)     Exons: 9     NC_000001.11
• OMIM: 612178

Protein Summary

• Protein general information: Q5T8I9  
  • Name: Small RNA 2' O methyltransferase (EC 2.1.1.n8) (HEN1 methyltransferase homolog 1)
  • Length: 393  
  • Mass: 44525
• Sequence:

  MEENNLQCSSVVDGNFEEVPRETAIQFKPPLYRQRYQFVKNLVDQHEPKKVADLGCGDTSLLRLLKVNPCIELLV
  GVDINEDKLRWRGDSLAPFLGDFLKPRDLNLTITLYHGSVVERDSRLLGFDLITCIELIEHLDSGDLARFPEVVF
  GYLSPSMIVISTPNSEFNPLFPSVTLRDSDHKFEWTRMEFQTWALYVANRYDYSVEFTGVGEPPAGAENVGYCTQ
  IGIFRKNGGKATESCLSEQHDQHVYKAVFTTSYPSLQQERFFKLVLVNEVSQQVESLRVSHLPRRKEQAGERGDK
  PKDIGGSKAPVPCFGPVFTEVEKAKIENSPTPFCVGDKFFVPLQRLLAYPKLNRLCANEEMMRSVIADSIPLSSD
  GSAVVADLRNYFDEQFEF

• Structural information:
  • Interpro: IPR026610  IPR029063  
  • PDB: 4XCX 5WY0
  • PDBsum: 4XCX 5WY0
  • STRING: ENSP00000359049
• Other Databases: GeneCards:  HENMT1  Malacards:  HENMT1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030422	production of siRNA involved in RNA interference	IBA	biological process
GO:0034587	piRNA metabolic process	IBA	biological process
GO:0008173	RNA methyltransferase activity	IBA	molecular function
GO:0008171	O-methyltransferase activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0043186	P granule	ISS	cellular component
GO:0001510	RNA methylation	ISS	biological process
GO:0034587	piRNA metabolic process	ISS	biological process
GO:0008173	RNA methyltransferase activity	ISS	molecular function
GO:0008171	O-methyltransferase activity	ISS	molecular function
GO:0001510	RNA methylation	IEA	biological process
GO:0008171	O-methyltransferase activity	IEA	molecular function
GO:0008173	RNA methyltransferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0031047	gene silencing by RNA	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0034587	piRNA metabolic process	IEA	biological process
GO:0008173	RNA methyltransferase activity	IEA	molecular function
GO:0008171	O-methyltransferase activity	IEA	molecular function
GO:0001510	RNA methylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)