• Gene id: 113201

Gene Summary

• Gene Symbol: GOLM2   Gene   UCSC   Ensembl
• Aliases: CASC4, H63
• Gene name: golgi membrane protein 2
• Alternate names: protein CASC4, cancer susceptibility 4, cancer susceptibility candidate 4, cancer susceptibility candidate gene 4 protein, gene associated with HER-2/neu overexpression,
• Gene location: 15q15.3 (44288708: 44415757)     Exons: 12     NC_000015.10
• Gene summary(Entrez): The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alte

Protein Summary

• Protein general information: Q6P4E1  
  • Name: Protein CASC4 (Cancer susceptibility candidate gene 4 protein)
  • Length: 436  
  • Mass: 49498
• Sequence:

  MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVD
  THKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKN
  NTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVA
  DKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPP
  DSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSK
  LADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL

• Structural information:
  • Interpro: IPR026141  IPR026139  
  • STRING: ENSP00000299957
• Other Databases: GeneCards:  GOLM2  Malacards:  GOLM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray