• Gene id: 112817

Gene Summary

• Gene Symbol: HOGA1   Gene   UCSC   Ensembl
• Aliases: C10orf65, DHDPS2, DHDPSL, HP3, NPL2
• Gene name: 4-hydroxy-2-oxoglutarate aldolase 1
• Alternate names: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial, DHDPS-like protein, N-acetylneuraminate pyruvate lyase 2 (putative), dihydrodipicolinate synthase-like, mitochondrial, dihydrodipicolinate synthetase homolog 2, probable 2-keto-4-hydroxyglutarate aldolase, proba,
• Gene location: 10q24.2 (97584344: 97612801)     Exons: 7     NC_000010.11
• Gene summary(Entrez): The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate syntha
• OMIM: 608570

Protein Summary

• Protein general information: Q86XE5  
  • Name: 4 hydroxy 2 oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase like) (DHDPS like protein) (Probable 2 keto 4 hydroxyglutarate aldolase) (Probable KHG aldolase) (Protein 569272)
  • Length: 327  
  • Mass: 35249
• Sequence:

  MLGPQVWSSVRQGLSRSLSRNVGVWASGEGKKVDIAGIYPPVTTPFTATAEVDYGKLEENLHKLGTFPFRGFVVQ
  GSNGEFPFLTSSERLEVVSRVRQAMPKNRLLLAGSGCESTQATVEMTVSMAQVGADAAMVVTPCYYRGRMSSAAL
  IHHYTKVADLSPIPVVLYSVPANTGLDLPVDAVVTLSQHPNIVGMKDSGGDVTRIGLIVHKTRKQDFQVLAGSAG
  FLMASYALGAVGGVCALANVLGAQVCQLERLCCTGQWEDAQKLQHRLIEPNAAVTRRFGIPGLKKIMDWFGYYGG
  PCRAPLQELSPAEEEALRMDFTSNGWL

• Structural information:
  • Interpro: IPR013785  IPR002220  IPR020625  
  • Prosite: PS00666
  • PDB: 3S5N 3S5O
  • PDBsum: 3S5N 3S5O
  • STRING: ENSP00000359680
• Other Databases: GeneCards:  HOGA1  Malacards:  HOGA1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008700	4-hydroxy-2-oxoglutarate aldolase activity	ISS	molecular function
GO:0016829	lyase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0016829	lyase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0008700	4-hydroxy-2-oxoglutarate aldolase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0046487	glyoxylate metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008700	4-hydroxy-2-oxoglutarate aldolase activity	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0046487	glyoxylate metabolic process	IDA	biological process
GO:0019470	4-hydroxyproline catabolic process	IDA	biological process
GO:0042866	pyruvate biosynthetic process	IDA	biological process
GO:0005739	mitochondrion	ISS	cellular component
GO:0033609	oxalate metabolic process	IMP	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0009436	glyoxylate catabolic process	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00330	Arginine and proline metabolism
hsa00630	Glyoxylate and dicarboxylate metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq