• Gene id: 112487

Gene Summary

• Gene Symbol: DTD2   Gene   UCSC   Ensembl
• Aliases: ATD, C14orf126
• Gene name: D-aminoacyl-tRNA deacylase 2
• Alternate names: D-aminoacyl-tRNA deacylase 2, D-tyrosyl-tRNA deacylase 2 (putative), D-tyrosyl-tRNA(Tyr) deacylase 2, L-alanyl-tRNA deacylase, animalia-specifc tRNA deacylase, animalia-specific tRNA deacylase, probable D-tyrosyl-tRNA(Tyr) deacylase 2, putative D-tyrosyl-tRNA de,
• Gene location: 14q12 (83114728: 83090047)     Exons: 6     NC_000004.12

Protein Summary

• Protein general information: Q96FN9  
  • Name: D aminoacyl tRNA deacylase 2 (EC 3.1.1.96) (Animalia specific tRNA deacylase) (ATD) (D tyrosyl tRNA(Tyr) deacylase 2) (L alanyl tRNA deacylase)
  • Length: 168  
  • Mass: 18660
• Sequence:

  MAEGSRIPQARALLQQCLHARLQIRPADGDVAAQWVEVQRGLVIYVCFFKGADKELLPKMVNTLLNVKLSETENG
  KHVSILDLPGNILIIPQATLGGRLKGRNMQYHSNSGKEEGFELYSQFVTLCEKEVAANSKCAEARVVVEHGTYGN
  RQVLKLDTNGPFTHLIEF

• Structural information:
  • Interpro: IPR003732  IPR023509  
  • STRING: ENSP00000312224
• Other Databases: GeneCards:  DTD2  Malacards:  DTD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002161	aminoacyl-tRNA editing activity	IBA	molecular function
GO:0006399	tRNA metabolic process	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	IBA	molecular function
GO:0002161	aminoacyl-tRNA editing activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051499	D-aminoacyl-tRNA deacylase activity	IEA	molecular function
GO:0000049	tRNA binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051499	D-aminoacyl-tRNA deacylase activity	IEA	molecular function
GO:0106105	Ala-tRNA(Thr) hydrolase activity	IEA	molecular function
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	IEA	biological process
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	IEA	molecular function
GO:0005737	cytoplasm	NAS	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0106105	Ala-tRNA(Thr) hydrolase activity	IDA	molecular function
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	IDA	biological process
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray