• Gene id: 112483

Gene Summary

• Gene Symbol: SAT2   Gene   UCSC   Ensembl
• Aliases: SSAT2
• Gene name: spermidine/spermine N1-acetyltransferase family member 2
• Alternate names: diamine acetyltransferase 2, diamine N-acetyltransferase 2, polyamine N-acetyltransferase 2, spermidine/spermine N(1)-acetyltransferase 2, thialysine N-epsilon-acetyltransferase,
• Gene location: 17p13.1 (7627877: 7626233)     Exons: 6     NC_000017.11
• OMIM: 611463

Protein Summary

• Protein general information: Q96F10  
  • Name: Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N acetyltransferase 2) (Spermidine/spermine N(1) acetyltransferase 2) (Thialysine N epsilon acetyltransferase)
  • Length: 170  
  • Mass: 19155
  • Tissue specificity: Widely expressed.
• Sequence:

  MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNPFYHCLVAEILPAPGKLLGPCVVGYG
  IYYFIYSTWKGRTIYLEDIYVMPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTE
  AEGWHFFCFQGEATRKLAGK

• Structural information:
  • Protein Domains: (4..16-)
    (/note="N-acetyltransferase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00532"-)
  • Interpro: IPR016181  IPR000182  IPR032959  
  • Prosite: PS51186
  • PDB: 2BEI 2Q4V
  • PDBsum: 2BEI 2Q4V
  • STRING: ENSP00000269298
• Other Databases: GeneCards:  SAT2  Malacards:  SAT2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032918	spermidine acetylation	IBA	biological process
GO:0019809	spermidine binding	IBA	molecular function
GO:0008080	N-acetyltransferase activity	IBA	molecular function
GO:0004145	diamine N-acetyltransferase activity	IBA	molecular function
GO:0008080	N-acetyltransferase activity	IEA	molecular function
GO:0016746	transferase activity, transferring acyl groups	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004145	diamine N-acetyltransferase activity	IEA	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0009447	putrescine catabolic process	IEA	biological process
GO:0032920	putrescine acetylation	IDA	biological process
GO:0032918	spermidine acetylation	IDA	biological process
GO:0032919	spermine acetylation	IDA	biological process
GO:0046204	nor-spermidine metabolic process	IDA	biological process
GO:0004145	diamine N-acetyltransferase activity	IDA	molecular function
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00330	Arginine and proline metabolism
hsa04216	Ferroptosis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881