• Gene id: 11223

Gene Summary

• Gene Symbol: MST1L   Gene   UCSC   Ensembl
• Aliases: BRF-1, D1F15S1A, MSPL-7, MSPL7, MST1P9, MSTP7, MSTP9
• Gene name: macrophage stimulating 1 like
• Alternate names: putative macrophage stimulating 1-like protein, brain-rescue-factor-1, macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 9, macrophage stimulating, pseudogene 7, macrophage stimulating, pseudogene 9, putative macrophage-stimulating protein MS,
• Gene location: 1p36.13 (16764479: 16754633)     Exons: 15     NC_000001.11
• OMIM: 604637

Protein Summary

• Protein general information: Q2TV78  
  • Name: Putative macrophage stimulating 1 like protein (Brain rescue factor 1) (BRF 1) (Hepatocyte growth factor like protein homolog)
  • Length: 715  
  • Mass: 79694
• Sequence:

  MAPAPVTLLAPGAASSMSCSQPGQRSPSNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRCGPLMDCWAFH
  YNVSSHGCQLLPWTQHSPHSRLWHSGRCDLFQEKGEWGYMPTLRNGLEENFCRNPDGDPGGPWCHTTDPAVRFQS
  CSIKSCRVAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTD
  PQIEREFCDLPRCGSEAQPRQEATSVSCFRGKGEGYRGTANTTTAAYLASVGTRKSHISTDLRQKNTRASEVGGG
  AGVGTCCCGDLRENFCWNLDGSEAPWCFTLRPGTRVGFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQC
  QRWSAETPHKLQALTLGRHALMSGTRAWKWLRLPCHDFAPAPASVHIYLRTACTTGGELLPDPDGDSHGPWCYTM
  DPRTPFDYCALRRCDQVQFEKCGKRVDRLDQRRSKLRVAGGHPGNSPWTVSLRNRQGQHFCAGSLVKEQWILTAR
  QCFSSCHMPLTGYEVWLGTLFQNPQHGEPGLQRVPVAKMLCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVV
  PPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGHVRESEMCTEGLLAPVGACEGDYGGPLACFTHN
  CWVLKGIRIPNRVCTRSRWPAVFTRVSVFVDWIHKVMRLG

• Structural information:
  • Protein Domains: (21..11-)
    (/note="PAN-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00315-)
    (63..15-)
    (/note="Kringle-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00121-)
    (160..23-)
    (/note="Kringle-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00121";-)
  • Interpro: IPR024174  IPR000001  IPR013806  IPR018056  IPR038178   IPR003609  IPR009003  IPR001314  IPR001254  
  • Prosite: PS00021 PS50070 PS50948 PS50240
  • CDD: cd00108 cd00190
• Other Databases: GeneCards:  MST1L  Malacards:  MST1L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004252	serine-type endopeptidase activity	IBA	molecular function
GO:0033601	positive regulation of mammary gland epithelial cell proliferation	IBA	biological process
GO:0010758	regulation of macrophage chemotaxis	IBA	biological process
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq