|
Gene id |
11200 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
CHEK2 Gene UCSC Ensembl |
|
Aliases |
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 |
|
Gene name |
checkpoint kinase 2 |
|
Alternate names |
serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, cds1 homolog, checkpoint-like protein CHK2, |
|
Gene location |
22q12.1 (28741865: 28687742) Exons: 22 NC_000022.11
|
|
Gene summary(Entrez) |
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a fo
|
|
OMIM |
604373 |
|
|
|
|
| Associated diseases |
References |
| Cancer | GAD: 20729852 |
| Atherosclerosis | GAD: 19265784 |
| Optic Disk | GAD: 20548946 |
| Diabetes | GAD: 19855918 |
| Endometriosis | INFBASE: 25912412 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Asthenospermia | MIK: 29658237 |
| Male infertility | MIK: 29658237 |
| Cryptorchidism | MIK: 28606200 |
| Spermatogenic defects | MIK: 31037746 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29658237 |
Asthenospe
rmia, Male
infertili
ty
|
|
|
80 (normal cont
rol, oligozoosp
ermia (OS), ast
henospermia (AS
), and oligoast
henozoospermia
(OAS))
|
Male infertility |
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
28 men with az
oospermia
|
Male infertility |
Microarray
|
Show abstract |
|