• Gene id: 1119

Gene Summary

• Gene Symbol: CHKA   Gene   UCSC   Ensembl
• Aliases: CHK, CK, CKI, EK
• Gene name: choline kinase alpha
• Alternate names: choline kinase alpha, CHETK-alpha, ethanolamine kinase,
• Gene location: 11q13.2 (35880372: 35871490)     Exons: 4     NC_000017.11
• Gene summary(Entrez): The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation
• OMIM: 118491

Protein Summary

• Protein general information: P35790  
  • Name: Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
  • Length: 457  
  • Mass: 52,249
• Sequence:

  MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPP
  QPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGA
  ILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDIS
  AEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
  VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQ
  LHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFH
  QKRKLGV

• Structural information:
  • Interpro: IPR011009  
  • PDB: 2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTG 5FUT 5W6O
  • PDBsum: 2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTG 5FUT 5W6O
  • STRING: ENSP00000265689
• Other Databases: GeneCards:  CHKA  Malacards:  CHKA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004103	choline kinase activity	IDA	molecular function
GO:0004103	choline kinase activity	TAS	molecular function
GO:0004104	cholinesterase activity	IEA	molecular function
GO:0004305	ethanolamine kinase activity	IDA	molecular function
GO:0004305	ethanolamine kinase activity	TAS	molecular function
GO:0004871	signal transducer activity	TAS	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006580	ethanolamine metabolic process	IEA	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	IEA	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	IDA	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	TAS	biological process
GO:0006656	phosphatidylcholine biosynthetic process	IDA	biological process
GO:0006656	phosphatidylcholine biosynthetic process	TAS	biological process
GO:0006657	CDP-choline pathway	IEA	biological process
GO:0006869	lipid transport	TAS	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0008144	drug binding	IDA	molecular function
GO:0009636	response to toxic substance	IEA	biological process
GO:0016310	phosphorylation	IEA	biological process
GO:0019695	choline metabolic process	IEA	biological process
GO:0033265	choline binding	IEA	molecular function
GO:0042803	protein homodimerization activity	IEA	molecular function
GO:1904681	response to 3-methylcholanthrene	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004103	choline kinase activity	IEA	molecular function
GO:0004103	choline kinase activity	IEA	molecular function
GO:0004103	choline kinase activity	TAS	molecular function
GO:0004103	choline kinase activity	IDA	molecular function
GO:0004103	choline kinase activity	TAS	molecular function
GO:0004104	cholinesterase activity	IEA	molecular function
GO:0004305	ethanolamine kinase activity	IEA	molecular function
GO:0004305	ethanolamine kinase activity	IEA	molecular function
GO:0004305	ethanolamine kinase activity	IDA	molecular function
GO:0004305	ethanolamine kinase activity	TAS	molecular function
GO:0004871	signal transducer activity	TAS	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006580	ethanolamine metabolic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	IEA	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	IDA	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	TAS	biological process
GO:0006656	phosphatidylcholine biosynthetic process	IEA	biological process
GO:0006656	phosphatidylcholine biosynthetic process	IEA	biological process
GO:0006656	phosphatidylcholine biosynthetic process	IDA	biological process
GO:0006656	phosphatidylcholine biosynthetic process	TAS	biological process
GO:0006657	CDP-choline pathway	IEA	biological process
GO:0006869	lipid transport	TAS	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0008144	drug binding	IDA	molecular function
GO:0008654	phospholipid biosynthetic process	IEA	biological process
GO:0009636	response to toxic substance	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0019695	choline metabolic process	IEA	biological process
GO:0033265	choline binding	IEA	molecular function
GO:0042803	protein homodimerization activity	IEA	molecular function
GO:1904681	response to 3-methylcholanthrene	IEA	biological process
GO:0004103	choline kinase activity	TAS	molecular function
GO:0004103	choline kinase activity	IDA	molecular function
GO:0004103	choline kinase activity	TAS	molecular function
GO:0004305	ethanolamine kinase activity	IDA	molecular function
GO:0004305	ethanolamine kinase activity	TAS	molecular function
GO:0004871	signal transducer activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006629	lipid metabolic process	TAS	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	IDA	biological process
GO:0006646	phosphatidylethanolamine biosynthetic process	TAS	biological process
GO:0006656	phosphatidylcholine biosynthetic process	IDA	biological process
GO:0006656	phosphatidylcholine biosynthetic process	TAS	biological process
GO:0006869	lipid transport	TAS	biological process
GO:0008144	drug binding	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa05231	Choline metabolism in cancer

Diseases

Associated diseases	References
Neural tube defects	GAD: 17184542
Cleft defects	GAD: 19737740
Ectopic pregnancy	INFBASE: 8566277
Oligozoospermia	MIK: 11549497
Oligozoospermia	MIK: 2331374
Oligozoospermia	MIK: 9052941
Oligozoospermia	MIK: 11549497
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Oligospermia	MIK: 11549497
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
11549497	Oligospermia			76 (51 oligospermic men (24 varicocele, 17unexplained infertility, 9 vasectomy reversal, 1 unknown diagnosis), 25 healthy donors)	Male infertility
2331374	Oligospermia			159 (109 normospermia, 50 oligospermia)	Male infertility
9052941	Oligospermic			145 (50 oligospermic, 95 normospermic)	Male infertility	LDH CK
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R