• Gene id: 11169

Gene Summary

• Gene Symbol: WDHD1   Gene   UCSC   Ensembl
• Aliases: AND-1, AND1, CHTF4, CTF4
• Gene name: WD repeat and HMG-box DNA binding protein 1
• Alternate names: WD repeat and HMG-box DNA-binding protein 1, Acidic nucleoplasmic DNA-binding protein 1, CTF4, chromosome transmission fidelity factor 4 homolog,
• Gene location: 14q22.2-q22.3 (55027105: 54938948)     Exons: 26     NC_000014.9
• Gene summary(Entrez): The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pr
• OMIM: 146690

Protein Summary

• Protein general information: O75717  
  • Name: WD repeat and HMG box DNA binding protein 1 (Acidic nucleoplasmic DNA binding protein 1) (And 1)
  • Length: 1129  
  • Mass: 125967
• Sequence:

  MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNT
  IQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIF
  LASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLS
  DNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLL
  ENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSH
  ILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWN
  SIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEW
  IIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLG
  VQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHY
  WVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYE
  ESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTA
  TQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKS
  GAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASA
  ASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEG
  MIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFA
  FKQE

• Structural information:
  • Interpro: IPR024977  IPR009071  IPR036910  IPR022100  IPR015943   IPR001680  IPR019775  IPR017986  IPR036322  
  • Prosite: PS50118 PS00678 PS50082 PS50294
  • PDB: 2D7L 5GVA 5GVB 5OGS
  • PDBsum: 2D7L 5GVA 5GVB 5OGS
  • STRING: ENSP00000353793
• Other Databases: GeneCards:  WDHD1  Malacards:  WDHD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000278	mitotic cell cycle	IBA	biological process
GO:0003682	chromatin binding	IBA	molecular function
GO:0006281	DNA repair	IBA	biological process
GO:0031298	replication fork protection complex	IBA	cellular component
GO:0043596	nuclear replication fork	IBA	cellular component
GO:0006261	DNA-dependent DNA replication	IBA	biological process
GO:0006974	cellular response to DNA damage stimulus	IBA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	TAS	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881