• Gene id: 11164

Gene Summary

• Gene Symbol: NUDT5   Gene   UCSC   Ensembl
• Aliases: YSA1, YSA1H, YSAH1, hNUDT5
• Gene name: nudix hydrolase 5
• Alternate names: ADP-sugar pyrophosphatase, 8-oxo-dGDP phosphatase, nuclear ATP-synthesis protein NUDIX5, nudix (nucleoside diphosphate linked moiety X)-type motif 5,
• Gene location: 10p14 (12196143: 12165327)     Exons: 11     NC_000010.11
• Gene summary(Entrez): This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP.
• OMIM: 609230

Protein Summary

• Protein general information: Q9UKK9  
  • Name: ADP sugar pyrophosphatase (EC 3.6.1.13) (8 oxo dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)
  • Length: 219  
  • Mass: 24328
  • Tissue specificity: Widely expressed. Most abundant in liver. {ECO
• Sequence:

  MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTADGVAVIPVLQRTLHYE
  CIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYKGDIAECSPAVCMDPGLSNCTIHIVTVTING
  DDAENARPKPKPGDGEFVEVISLPKNDLLQRLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF

• Structural information:
  • Protein Domains: (57..19-)
    (/note="Nudix-hydrolase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00794"-)
  • Interpro: IPR020476  IPR015797  IPR020084  IPR000086  
  • Prosite: PS51462 PS00893
  • PDB: 2DSB 2DSC 2DSD 3AC9 3ACA 3BM4 3L85 5NQR 5NWH 5QJ4 5QJ5 5QJ6 5QJ7 5QJ8 5QJ9 5QJA 5QJB 5QJC 5QJD 5QJE 5QJF 5QJG 5QJH 5QJI 5QJJ 5QJK 5QJL 5QJM 5QJN 5QJO 5QJP 5QJQ 5QJR 5QJS 5QJT 5QJU 5QJV 5QJW 5QJX 5QJY 5QJZ 5QK0 5QK1 5QK2 5QK3 5QK4 5QK5 5QK6 5QK7 5QK8 5QK9 5QKA 5QTL 5QTM 5QTN 5QTO 5QTP 5QTQ 5QTR 5QTS 6GRU
  • PDBsum: 2DSB 2DSC 2DSD 3AC9 3ACA 3BM4 3L85 5NQR 5NWH 5QJ4 5QJ5 5QJ6 5QJ7 5QJ8 5QJ9 5QJA 5QJB 5QJC 5QJD 5QJE 5QJF 5QJG 5QJH 5QJI 5QJJ 5QJK 5QJL 5QJM 5QJN 5QJO 5QJP 5QJQ 5QJR 5QJS 5QJT 5QJU 5QJV 5QJW 5QJX 5QJY 5QJZ 5QK0 5QK1 5QK2 5QK3 5QK4 5QK5 5QK6 5QK7 5QK8 5QK9 5QKA 5QTL 5QTM 5QTN 5QTO 5QTP 5QTQ 5QTR 5QTS 6GRU
  • STRING: ENSP00000419628
• Other Databases: GeneCards:  NUDT5  Malacards:  NUDT5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0047631	ADP-ribose diphosphatase activity	IBA	molecular function
GO:0019693	ribose phosphate metabolic process	IBA	biological process
GO:0006753	nucleoside phosphate metabolic process	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0019144	ADP-sugar diphosphatase activity	IDA	molecular function
GO:0009191	ribonucleoside diphosphate catabolic process	IDA	biological process
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0016779	nucleotidyltransferase activity	IDA	molecular function
GO:0009191	ribonucleoside diphosphate catabolic process	IDA	biological process
GO:0019303	D-ribose catabolic process	IDA	biological process
GO:0047631	ADP-ribose diphosphatase activity	IDA	molecular function
GO:0009191	ribonucleoside diphosphate catabolic process	IDA	biological process
GO:0006338	chromatin remodeling	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:1990966	ATP generation from poly-ADP-D-ribose	IDA	biological process
GO:0044715	8-oxo-dGDP phosphatase activity	IDA	molecular function
GO:0044715	8-oxo-dGDP phosphatase activity	IDA	molecular function
GO:0050072	m7G(5')pppN diphosphatase activity	ISS	NOT|molecular function
GO:0030515	snoRNA binding	ISS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0009117	nucleotide metabolic process	NAS	biological process
GO:0009191	ribonucleoside diphosphate catabolic process	TAS	biological process
GO:0047631	ADP-ribose diphosphatase activity	IEA	molecular function
GO:0047631	ADP-ribose diphosphatase activity	EXP	molecular function
GO:0047631	ADP-ribose diphosphatase activity	EXP	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0034656	nucleobase-containing small molecule catabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0017110	nucleoside-diphosphatase activity	IEA	molecular function
GO:0030515	snoRNA binding	IEA	molecular function
GO:0006139	nucleobase-containing compound metabolic process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0019144	ADP-sugar diphosphatase activity	IDA	molecular function
GO:0005634	nucleus	HDA	cellular component
GO:0019303	D-ribose catabolic process	NAS	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00230	Purine metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq