• Gene id: 1116

Gene Summary

• Gene Symbol: CHI3L1   Gene   UCSC   Ensembl
• Aliases: ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40, hCGP-39
• Gene name: chitinase 3 like 1
• Alternate names: chitinase-3-like protein 1, 39 kDa synovial protein, cartilage glycoprotein 39, chitinase 3-like 1 (cartilage glycoprotein-39),
• Gene location: 1q32.1 (203186703: 203178930)     Exons: 10     NC_000001.11
• Gene summary(Entrez): Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein membe
• OMIM: 601525

Protein Summary

• Protein general information: P36222  
  • Name: Chitinase 3 like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP 39) (GP 39) (hCGP 39) (YKL 40)
  • Length: 383  
  • Mass: 42625
  • Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibrobla
• Sequence:

  MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVT
  LYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHF
  TTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRG
  QEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEIC
  DFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNA
  IKDALAAT

• Structural information:
  • Protein Domains: (22..38-)
    (/note="GH18-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01258"-)
  • Interpro: IPR028538  IPR011583  IPR029070  IPR001223  IPR017853  
  • Prosite: PS51910
  • PDB: 1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
  • PDBsum: 1HJV 1HJW 1HJX 1LA7 1NWR 1NWS 1NWT 1NWU
  • STRING: ENSP00000255409
• Other Databases: GeneCards:  CHI3L1  Malacards:  CHI3L1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005576	extracellular region	IBA	cellular component
GO:0008061	chitin binding	IBA	molecular function
GO:0004568	chitinase activity	IBA	NOT|molecular function
GO:0006032	chitin catabolic process	IBA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0008061	chitin binding	IEA	molecular function
GO:0045766	positive regulation of angiogenesis	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0006915	apoptotic process	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0035580	specific granule lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0071356	cellular response to tumor necrosis factor	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0007250	activation of NF-kappaB-inducing kinase activity	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0071347	cellular response to interleukin-1	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0072606	interleukin-8 secretion	IEA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IEA	biological process
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008061	chitin binding	IDA	molecular function
GO:0008061	chitin binding	IDA	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0004568	chitinase activity	IDA	NOT|molecular function
GO:0004568	chitinase activity	IDA	NOT|molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005615	extracellular space	HDA	cellular component
GO:0071356	cellular response to tumor necrosis factor	ISS	biological process
GO:0070555	response to interleukin-1	IEP	biological process
GO:0051216	cartilage development	NAS	biological process
GO:0034612	response to tumor necrosis factor	IEP	biological process
GO:0009612	response to mechanical stimulus	IEP	biological process
GO:0005201	extracellular matrix structural constituent	NAS	molecular function
GO:0072606	interleukin-8 secretion	ISS	biological process
GO:0070741	response to interleukin-6	IEP	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	biological process
GO:0045766	positive regulation of angiogenesis	IMP	biological process
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0007250	activation of NF-kappaB-inducing kinase activity	ISS	biological process
GO:0005783	endoplasmic reticulum	ISS	cellular component
GO:0031012	extracellular matrix	NAS	cellular component
GO:0051897	positive regulation of protein kinase B signaling	IMP	biological process
GO:0030324	lung development	IMP	biological process
GO:0006954	inflammatory response	IEP	biological process

Diseases

Associated diseases	References
Schizophrenia	KEGG:H01649
Schizophrenia	KEGG:H01649
Cancer (small cell)	PMID:15541818
colorectal carcinoma	PMID:12124825
Prostate cancer	PMID:16372331
Pre-eclampsia	PMID:18054022
Temporal arteritis	PMID:10616010
pulmonary sarcoidosis	PMID:15763444
Endometrial cancer	PMID:17023034
Breast cancer	PMID:12889595
Melanoma	PMID:16456816
Arteriosclerosis	PMID:10073974
Ovarian cancer	PMID:12883737
Asthma	PMID:18003958
Asthma	PMID:19568425
Glioblastoma multiforme	PMID:11161003
Chronic obstructive pulmonary disease	PMID:20656949
chondrosarcoma	PMID:12598313
Coronary artery disease	PMID:17627189
Pulmonary fibrosis	PMID:20888745
lung non-small cell carcinoma	PMID:20564116
systemic scleroderma	PMID:16195162
Myocardial infarction	PMID:18480670
congestive heart failure	PMID:19961288
Rheumatoid arthritis	PMID:10461474
acute myeloid leukemia	PMID:16361549
type 2 diabetes mellitus	PMID:21143859
multiple myeloma	PMID:16930142
type 1 diabetes mellitus	PMID:18957531
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq