|
Gene id |
1111 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
CHEK1 Gene UCSC Ensembl |
|
Aliases |
CHK1 |
|
Gene name |
checkpoint kinase 1 |
|
Alternate names |
serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint, S. pombe, homolog of, 1, Chk1-S, cell cycle checkpoint kinase, |
|
Gene location |
11q24.2 (125624909: 125676255) Exons: 15 NC_000011.10
|
|
Gene summary(Entrez) |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR,
|
|
OMIM |
603078 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
|
|
|
|
|
| Associated diseases |
References |
| Colorectal cancer | GAD: 17879369 |
| Cancer (pancreatic) | GAD: 18381943 |
| Cancer (lung) | GAD: 18676680 |
| Esophageal adenocarcinoma | GAD: 20453000 |
| Brain neoplasms | GAD: 17684142 |
| Cancer (bladder) | GAD: 19692168 |
| Epithelial ovarian cancer | GAD: 19064572 |
| Colorectal cancer | GAD: 17408908 |
| Adenocarcinoma | GAD: 19690177 |
| Chronic renal failure | GAD: 21085059 |
| Associated with semen quality | MIK: 21171266 |
| Asthenozoospermia | MIK: 29658237 |
| Chronic obstructive pulmonary disease (COPD) | GAD: 19625176 |
| Associated with semen quality | MIK: 21171266 |
| Asthenospermia | MIK: 29658237 |
| Male infertility | MIK: 29658237 |
| Cryptorchidism | MIK: 28606200 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 21171266 |
Associated
with seme
n quality
|
|
|
80 (4 groups of
equal number:
normal, oligosp
ermia, asthenoz
oospermia and o
ligoasthenozoos
permia)
|
Male infertility |
|
Show abstract |
| 29658237 |
Asthenospe
rmia, Male
infertili
ty
|
|
|
80 (normal cont
rol, oligozoosp
ermia (OS), ast
henospermia (AS
), and oligoast
henozoospermia
(OAS))
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|