• Gene id: 11103

Gene Summary

• Gene Symbol: KRR1   Gene   UCSC   Ensembl
• Aliases: HRB2, RIP-1
• Gene name: KRR1 small subunit processome component homolog
• Alternate names: KRR1 small subunit processome component homolog, HIV-1 Rev-binding protein 2, HIV-1 rev binding protein 2, KRR-R motif-containing protein 1, KRR1, small subunit (SSU) processome component, homolog, Rev interacting protein, rev-interacting protein 1,
• Gene location: 12q21.2 (75511608: 75490862)     Exons: 6     NC_000012.12
• OMIM: 612817

Protein Summary

• Protein general information: Q13601  
  • Name: KRR1 small subunit processome component homolog (HIV 1 Rev binding protein 2) (KRR R motif containing protein 1) (Rev interacting protein 1) (Rip 1)
  • Length: 381  
  • Mass: 43665
• Sequence:

  MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKEC
  WPLVQKALNEHHVNATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQAVRILQDDVACDIIKIGSL
  VRNKERFVKRRQRLIGPKGSTLKALELLTNCYIMVQGNTVSAIGPFSGLKEVRKVVLDTMKNIHPIYNIKSLMIK
  RELAKDSELRSQSWERFLPQFKHKNVNKRKEPKKKTVKKEYTPFPPPQPESQIDKELASGEYFLKANQKKRQKME
  AIKAKQAEAISKRQEERNKAFIPPKEKPIVKPKEASTETKIDVASIKEKVKKAKNKKLGALTAEEIALKMEADEK
  KKKKKK

• Structural information:
  • Protein Domains: (154..20-)
    (/note="KH"-)
  • Interpro: IPR041174  IPR004087  IPR036612  IPR024166  
  • STRING: ENSP00000229214
• Other Databases: GeneCards:  KRR1  Malacards:  KRR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032040	small-subunit processome	IBA	cellular component
GO:0005730	nucleolus	IBA	cellular component
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0042254	ribosome biogenesis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0006364	rRNA processing	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006364	rRNA processing	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0045171	intercellular bridge	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881