• Gene id: 11092

Gene Summary

• Gene Symbol: SPACA9   Gene   UCSC   Ensembl
• Aliases: C9orf9, Mast
• Gene name: sperm acrosome associated 9
• Alternate names: sperm acrosome-associated protein 9, Rsb66 homolog,
• Gene location: 9q34.13 (123195247: 123069871)     Exons: 7     NC_000011.10
• OMIM: 618552

Protein Summary

• Protein general information: Q96E40  
  • Name: Sperm acrosome associated protein 9
  • Length: 222  
  • Mass: 25166
• Sequence:

  MNEVKESLRSIEQKYKLFQQQQLTFTAALEHCRENAHDKIRPISSIGQVQSYMEHYCNSSTDRRVLLMFLDICSE
  LNKLCQHFEAVHSGTPVTNNLLEKCKTLVSQSNDLSSLRAKYPHDVVNHLSCDEARNHYGGVVSLIPLILDLMKE
  WIAHSEKLPRKVLQHVSEPQAHQESTRGAARPAQAIGTQPRATKHKCRQLTKASLKPRGCSKPPWRPPGGKL

• Structural information:
  • Interpro: IPR027818  
  • STRING: ENSP00000298546
• Other Databases: GeneCards:  SPACA9  Malacards:  SPACA9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001669	acrosomal vesicle	IBA	cellular component
GO:0036126	sperm flagellum	IBA	cellular component
GO:0097546	ciliary base	IBA	cellular component
GO:0005881	cytoplasmic microtubule	IDA	cellular component
GO:0036064	ciliary basal body	ISS	cellular component
GO:0005634	nucleus	ISS	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0097546	ciliary base	IEA	cellular component
GO:0036064	ciliary basal body	IEA	cellular component
GO:0048306	calcium-dependent protein binding	IEA	molecular function
GO:0036126	sperm flagellum	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001669	acrosomal vesicle	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0001669	acrosomal vesicle	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R