• Gene id: 11005

Gene Summary

• Gene Symbol: SPINK5   Gene   UCSC   Ensembl
• Aliases: LEKTI, LETKI, NETS, NS, VAKTI
• Gene name: serine peptidase inhibitor Kazal type 5
• Alternate names: serine protease inhibitor Kazal-type 5, lympho-epithelial Kazal-type-related inhibitor, lymphoepithelial Kazal-type-related inhibitor,
• Gene location: 5q32 (148063979: 148137381)     Exons: 34     NC_000005.10
• Gene summary(Entrez): This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. T
• OMIM: 605010

Protein Summary

• Protein general information: Q9NQ38  
  • Name: Serine protease inhibitor Kazal type 5 (Lympho epithelial Kazal type related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]
  • Length: 1064  
  • Mass: 120714
  • Tissue specificity: Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. {ECO
• Sequence:

  MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAK
  SQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGE
  CKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFC
  KEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY
  QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVR
  NGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLF
  CTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMH
  GNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
  SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKE
  NEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLERE
  AERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKE
  DEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD
  EEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRA
  SQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS
  TPGTTAASMPPSDE

• Structural information:
  • Protein Domains: (28..6-)
    (/note="Kazal-like-)
    (-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798-)
    (91..15-)
    (/note="Kazal-like-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798-)
    (155..21-)
    (/note="Kazal-like-3)
    (/evidence="ECO:0000255|PR-)
  • Interpro: IPR002350  IPR036058  
  • Prosite: PS00282 PS51465
  • PDB: 1H0Z 1HDL 1UUC 1UVF 1UVG 5YHN
  • PDBsum: 1H0Z 1HDL 1UUC 1UVF 1UVG 5YHN
  • STRING: ENSP00000352936
• Other Databases: GeneCards:  SPINK5  Malacards:  SPINK5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007417	central nervous system development	IBA	biological process
GO:0030154	cell differentiation	IBA	biological process
GO:1902572	negative regulation of serine-type peptidase activity	IBA	biological process
GO:0004867	serine-type endopeptidase inhibitor activity	IBA	molecular function
GO:0007275	multicellular organism development	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0010466	negative regulation of peptidase activity	IEA	biological process
GO:0030414	peptidase inhibitor activity	IEA	molecular function
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0070268	cornification	TAS	biological process
GO:1902572	negative regulation of serine-type peptidase activity	IEA	biological process
GO:0030414	peptidase inhibitor activity	IEA	molecular function
GO:0030155	regulation of cell adhesion	IEA	biological process
GO:1900004	negative regulation of serine-type endopeptidase activity	IEA	biological process
GO:0045861	negative regulation of proteolysis	IEA	biological process
GO:0002787	negative regulation of antibacterial peptide production	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0097209	epidermal lamellar body	IDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0009913	epidermal cell differentiation	IDA	biological process
GO:0005789	endoplasmic reticulum membrane	IDA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005576	extracellular region	IDA	cellular component
GO:0005938	cell cortex	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0004867	serine-type endopeptidase inhibitor activity	IDA	molecular function
GO:0004867	serine-type endopeptidase inhibitor activity	IDA	molecular function
GO:0030855	epithelial cell differentiation	TAS	biological process
GO:0045580	regulation of T cell differentiation	TAS	biological process
GO:0016525	negative regulation of angiogenesis	TAS	biological process
GO:0005576	extracellular region	NAS	cellular component
GO:0050777	negative regulation of immune response	TAS	biological process
GO:0051884	regulation of timing of anagen	TAS	biological process
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0035315	hair cell differentiation	TAS	biological process

Diseases

Associated diseases	References
Atopic dermatitis	KEGG:H01358
Netherton syndrome	KEGG:H00671
Atopic dermatitis	KEGG:H01358
Netherton syndrome	KEGG:H00671
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)