|
Gene id |
11004 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
KIF2C Gene UCSC Ensembl |
|
Aliases |
CT139, KNSL6, MCAK |
|
Gene name |
kinesin family member 2C |
|
Alternate names |
kinesin-like protein KIF2C, kinesin-like protein 6, mitotic centromere-associated kinesin, testis tissue sperm-binding protein Li 68n, |
|
Gene location |
1p34.1 (44739703: 44767766) Exons: 22 NC_000008.11
|
|
Gene summary(Entrez) |
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multip
|
|
OMIM |
604538 |
|
| Associated diseases |
References |
| Cancer (breast) | GAD: 20508983 |
| Associated with spermatogenesis and may be correlated with male infertility | MIK: 12383881 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Associated with spermatogenesis and may be correlated with male infertility | MIK: 12383881 |
| Non obstructive azoospermia | MIK: 23869807 |
| Sertoli cell only syndrome | MIK: 23869807 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 12383881 |
Assocaited
with sper
matogenesi
s and may
be correla
ted with m
ale infert
ility
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 23869807 |
Non obstru
ctive azoo
spermia, S
ertoli cel
l only syn
drome
|
|
|
20 (4 controls,
16 cases)
|
Male infertility |
GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
28 men with az
oospermia
|
Male infertility |
Microarray
|
Show abstract |
|