• Gene id: 10988

Gene Summary

• Gene Symbol: METAP2   Gene   UCSC   Ensembl
• Aliases: MAP2, MNPEP, p67eIF2
• Gene name: methionyl aminopeptidase 2
• Alternate names: methionine aminopeptidase 2, eIF-2-associated p67 homolog, initiation factor 2-associated 67 kDa glycoprotein, peptidase M 2, testicular tissue protein Li 17,
• Gene location: 12q22 (38229713: 38211005)     Exons: 14     NC_000019.10
• Gene summary(Entrez): The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal me
• OMIM: 601870

Protein Summary

• Protein general information: P50579  
  • Name: Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2 associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)
  • Length: 478  
  • Mass: 52892
• Sequence:

  MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSA
  LEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRT
  TSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSL
  NNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
  GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVH
  DDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDI
  KGSYTAQFEHTILLRPTCKEVVSRGDDY

• Structural information:
  • Interpro: IPR036005  IPR000994  IPR001714  IPR002468  IPR018349   IPR036388  IPR036390  
  • Prosite: PS01202
  • CDD: cd01088
  • PDB: 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ
  • PDBsum: 1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ
  • STRING: ENSP00000325312
• Other Databases: GeneCards:  METAP2  Malacards:  METAP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016485	protein processing	IDA	biological process
GO:0031365	N-terminal protein amino acid modification	IDA	biological process
GO:0018206	peptidyl-methionine modification	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008235	metalloexopeptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0022400	regulation of rhodopsin mediated signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0070084	protein initiator methionine removal	IEA	biological process
GO:0070006	metalloaminopeptidase activity	IEA	molecular function
GO:0004177	aminopeptidase activity	IDA	molecular function
GO:0008235	metalloexopeptidase activity	IDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)