• Gene id: 10930

Gene Summary

• Gene Symbol: APOBEC2   Gene   UCSC   Ensembl
• Aliases: ARCD1, ARP1
• Gene name: apolipoprotein B mRNA editing enzyme catalytic subunit 2
• Alternate names: C->U-editing enzyme APOBEC-2, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2, mRNA(cytosine(6666)) deaminase 2, probable C->U-editing enzyme APOBEC-2,
• Gene location: 6p21.1 (41053200: 41064890)     Exons: 3     NC_000006.12
• OMIM: 608119

Protein Summary

• Protein general information: Q9Y235  
  • Name: C >U editing enzyme APOBEC 2 (EC 3.5.4.36) (mRNA(cytosine(6666)) deaminase 2)
  • Length: 224  
  • Mass: 25703
  • Tissue specificity: Expressed exclusively in heart and skeletal muscle.
• Sequence:

  MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVE
  AQGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPALRYNVTWYVSSSPCAACADRIIKTLSKTKNLRLLIL
  VGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK

• Structural information:
  • Protein Domains: (64..16-)
    (/note="CMP/dCMP-type-deaminase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01083"-)
  • Interpro: IPR002125  IPR016193  
  • Prosite: PS51747
  • PDB: 2NYT
  • PDBsum: 2NYT
  • DIP: 60263
  • STRING: ENSP00000244669
• Other Databases: GeneCards:  APOBEC2  Malacards:  APOBEC2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003723	RNA binding	IBA	molecular function
GO:0004126	cytidine deaminase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0016554	cytidine to uridine editing	IBA	biological process
GO:0080111	DNA demethylation	IBA	biological process
GO:0080111	DNA demethylation	IDA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0003723	RNA binding	TAS	molecular function
GO:0004126	cytidine deaminase activity	TAS	molecular function
GO:0016554	cytidine to uridine editing	IDA	biological process
GO:0004126	cytidine deaminase activity	IDA	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0016556	mRNA modification	IEA	biological process
GO:0016554	cytidine to uridine editing	IEA	biological process
GO:0004126	cytidine deaminase activity	IEA	molecular function
GO:0009972	cytidine deamination	IEA	biological process
GO:0009972	cytidine deamination	IEA	biological process
GO:0009972	cytidine deamination	IEA	biological process
GO:0009972	cytidine deamination	IEA	biological process

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R