• Gene id: 10924

Gene Summary

• Gene Symbol: SMPDL3A   Gene   UCSC   Ensembl
• Aliases: ASM3A, ASML3a, yR36GH4.1
• Gene name: sphingomyelin phosphodiesterase acid like 3A
• Alternate names: acid sphingomyelinase-like phosphodiesterase 3a, 0610010C24Rik, ASM-like phosphodiesterase 3a,
• Gene location: 6q22.31 (65833639: 65855168)     Exons: 15     NC_000011.10
• OMIM: 610728

Protein Summary

• Protein general information: Q92484  
  • Name: Acid sphingomyelinase like phosphodiesterase 3a (ASM like phosphodiesterase 3a) (EC 3.1.4. )
  • Length: 453  
  • Mass: 51260
  • Tissue specificity: Detected in blood serum. Detected in macrophages (at protein level). {ECO
• Sequence:

  MALVRALVCCLLTAWHCRSGLGLPVAPAGGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGP
  FGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALG
  NHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTD
  PANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIM
  VLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILT
  QTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKAFQICAIMNLDNISYADCLKQLYIK
  HNY

• Structural information:
  • Interpro: IPR017064  IPR041805  IPR004843  IPR029052  
  • CDD: cd00842
  • PDB: 5EBB 5EBE
  • PDBsum: 5EBB 5EBE
  • STRING: ENSP00000357425
• Other Databases: GeneCards:  SMPDL3A  Malacards:  SMPDL3A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0008081	phosphoric diester hydrolase activity	IBA	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0004767	sphingomyelin phosphodiesterase activity	IDA	NOT|molecular function
GO:0008270	zinc ion binding	IDA	molecular function
GO:0009143	nucleoside triphosphate catabolic process	IDA	biological process
GO:0006685	sphingomyelin catabolic process	IDA	NOT|biological process
GO:0008081	phosphoric diester hydrolase activity	IDA	molecular function
GO:0005615	extracellular space	IMP	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881