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Gene id 109
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol ADCY3   Gene   UCSC   Ensembl
Aliases AC-III, AC3, BMIQ19
Gene name adenylate cyclase 3
Alternate names adenylate cyclase type 3, ATP pyrophosphate-lyase 3, adenylate cyclase type III, adenylate cyclase, olfactive type, adenylyl cyclase 3, adenylyl cyclase, type III,
Gene location 2p23.3 (24920236: 24819168)     Exons: 26     NC_000008.11
Gene summary(Entrez) This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involv
OMIM 600291

SNPs
rs700519

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000015.10   g.51215771G>A
NC_000015.9   g.51507968G>A
NG_007982.1   g.127828C>T
NM_000103.4   c.790C>T
NM_000103.3   c.790C>T
NM_031226.3   c.790C>T
NM_031226.2   c.790C>T
NM_001347255.2   c.790C>T
NM_001347255.1   c.790C>T
NM_001347256.2   c.790C>T
NM_001347256.1   c.

rs1877031

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000017.11   g.39657827G>A
NC_000017.10   g.37814080G>A
NM_006804.4   c.350G>A
NM_006804.3   c.350G>A
XM_017024041.2   c.350G>A
NM_001165937.1   c.350G>A
XM_024450549.1   c.-418G>A
NM_001165938.1   c.350G>A
NP_006795.3   p.Arg117Gln
XP_016879530.1   p.Arg117Gln
NP_001  

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04024cAMP signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04114Oocyte meiosis
hsa04540Gap junction
hsa04611Platelet activation
hsa04062Chemokine signaling pathway
hsa04911Insulin secretion
hsa04923Regulation of lipolysis in adipocytes
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04915Estrogen signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04921Oxytocin signaling pathway
hsa04926Relaxin signaling pathway
hsa04918Thyroid hormone synthesis
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04916Melanogenesis
hsa04925Aldosterone synthesis and secretion
hsa04927Cortisol synthesis and secretion
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa04962Vasopressin-regulated water reabsorption
hsa04724Glutamatergic synapse
hsa04727GABAergic synapse
hsa04725Cholinergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04211Longevity regulating pathway
hsa04213Longevity regulating pathway - multiple species
hsa04713Circadian entrainment
hsa04714Thermogenesis
hsa05200Pathways in cancer
hsa05032Morphine addiction
hsa05414Dilated cardiomyopathy
hsa04934Cushing syndrome
hsa05110Vibrio cholerae infection
hsa05166Human T-cell leukemia virus 1 infection
hsa05163Human cytomegalovirus infection
hsa01522Endocrine resistance
hsa01100Metabolic pathways
hsa05200Pathways in cancer
hsa04915Estrogen signaling pathway
hsa05166Human T-cell leukemia virus 1 infection
hsa04928Parathyroid hormone synthesis, secretion and action
hsa04714Thermogenesis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa05163Human cytomegalovirus infection
hsa04911Insulin secretion
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04020Calcium signaling pathway
hsa04725Cholinergic synapse
hsa04270Vascular smooth muscle contraction
hsa04015Rap1 signaling pathway
hsa04970Salivary secretion
hsa04925Aldosterone synthesis and secretion
hsa04713Circadian entrainment
hsa04935Growth hormone synthesis, secretion and action
hsa05032Morphine addiction
hsa04723Retrograde endocannabinoid signaling
hsa04211Longevity regulating pathway
hsa04371Apelin signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04611Platelet activation
hsa04918Thyroid hormone synthesis
hsa04976Bile secretion
hsa04114Oocyte meiosis
hsa04916Melanogenesis
hsa04972Pancreatic secretion
hsa04926Relaxin signaling pathway
hsa04727GABAergic synapse
hsa05110Vibrio cholerae infection
hsa04962Vasopressin-regulated water reabsorption
hsa04062Chemokine signaling pathway
hsa04971Gastric acid secretion
hsa04934Cushing syndrome
hsa04923Regulation of lipolysis in adipocytes
hsa04213Longevity regulating pathway - multiple species
hsa00230Purine metabolism
hsa04540Gap junction
hsa04927Cortisol synthesis and secretion
hsa01522Endocrine resistance
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04724Glutamatergic synapse
hsa05414Dilated cardiomyopathy
hsa04913Ovarian steroidogenesis
hsa04740Olfactory transduction

Diseases

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Associated diseases References
Obesity GAD: 17895882
Diabetes GAD: 17895882
Obesity KEGG: H02106
Spermatogenesis defects MIK: 15705663
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
It is required for spermatozoa function and male fertility MIK: 15705663
Male factor infertility MIK: 29961538
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
15705663 It is requ
ired for s
permatozoa
function
and male f
ertility

Male infertility
Show abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
29961538 Male facto
r infertil
ity
318 (128 couple
s presenting wi
th OAT (MF) and
118 maternal a
ge-matched cont
rol (no MF) sub
jects undergoin
g infertility t
reatment, 72 su
rplus cryoprese
rved blastocyst
s)
 Male infertility RNA-seq
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract