• Gene id: 10873

Gene Summary

• Gene Symbol: ME3   Gene   UCSC   Ensembl
• Aliases: NADP-ME
• Gene name: malic enzyme 3
• Alternate names: NADP-dependent malic enzyme, mitochondrial, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), malic enzyme 3, NADP(+)-dependent, mitochondrial, malic enzyme, NADP+-dependent, mitochondrial, mitochondrial NADP(+)-dependent malic enzyme 3, pyruvic-m,
• Gene location: 11q14.2 (86674745: 86441107)     Exons: 22     NC_000011.10
• Gene summary(Entrez): Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent is
• OMIM: 604164

Protein Summary

• Protein general information: Q16798  
  • Name: NADP dependent malic enzyme, mitochondrial (NADP ME) (EC 1.1.1.40) (Malic enzyme 3)
  • Length: 604  
  • Mass: 67068
  • Tissue specificity: Expressed predominantly in organs with a low-division rate.
• Sequence:

  MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGI
  HGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGL
  TFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLP
  VLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
  FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLI
  VKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAEC
  TAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVS
  EQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
  VQTV

• Structural information:
  • Interpro: IPR015884  IPR012301  IPR037062  IPR012302  IPR001891   IPR036291  
  • Prosite: PS00331
  • STRING: ENSP00000440246
• Other Databases: GeneCards:  ME3  Malacards:  ME3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005739	mitochondrion	IBA	cellular component
GO:0006090	pyruvate metabolic process	IBA	biological process
GO:0006108	malate metabolic process	IBA	biological process
GO:0004470	malic enzyme activity	IBA	molecular function
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	IBA	molecular function
GO:0004470	malic enzyme activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	IEA	molecular function
GO:0051287	NAD binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	IEA	molecular function
GO:0008948	oxaloacetate decarboxylase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0006099	tricarboxylic acid cycle	TAS	biological process
GO:0005759	mitochondrial matrix	IEA	cellular component
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0006090	pyruvate metabolic process	IDA	biological process
GO:0070401	NADP+ binding	IDA	molecular function
GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	IDA	molecular function
GO:0004470	malic enzyme activity	IDA	molecular function
GO:0006108	malate metabolic process	IDA	biological process
GO:0072592	oxygen metabolic process	TAS	biological process
GO:0009060	aerobic respiration	TAS	biological process
GO:0005739	mitochondrion	TAS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa03320	PPAR signaling pathway
hsa00620	Pyruvate metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq