• Gene id: 10846

Gene Summary

• Gene Symbol: PDE10A   Gene   UCSC   Ensembl
• Aliases: ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
• Gene name: phosphodiesterase 10A
• Alternate names: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 3',5' cAMP/cGMP phosphodiesterase, dJ416F21.1 (phosphodiesterase 10A), phosphodiesterase 10A1 (PDE10A1), phosphodiesterase 10A7 (PDE10A7),
• Gene location: 6q27 (165988114: 165327286)     Exons: 31     NC_000006.12
• Gene summary(Entrez): The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the co
• OMIM: 604095

Protein Summary

• Protein general information: Q9Y233  
  • Name: cAMP and cAMP inhibited cGMP 3',5' cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)
  • Length: 779  
  • Mass: 88412
  • Tissue specificity: Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum. {ECO
• Sequence:

  MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVV
  YELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTT
  VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATA
  NLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELY
  SDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSR
  GSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM
  QFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAH
  CMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNI
  FSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVT
  KLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLS
  QWEKVIRGEETATWISSPSVAQKAAASED

• Structural information:
  • Protein Domains: (91..23-)
    (/note="GAF-1)
    (266..41-)
    (/note="GAF-2)
    (442..75-)
    (/note="PDEase-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01192"-)
  • Interpro: IPR003018  IPR029016  IPR003607  IPR023088  IPR002073   IPR036971  IPR023174  
  • Prosite: PS00126 PS51845
  • CDD: cd00077
  • PDB: 1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS
  • PDBsum: 1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS
  • STRING: ENSP00000438284
• Other Databases: GeneCards:  PDE10A  Malacards:  PDE10A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0010754	negative regulation of cGMP-mediated signaling	IBA	biological process
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IBA	molecular function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IBA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	molecular function
GO:0008081	phosphoric diester hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0030553	cGMP binding	IEA	molecular function
GO:0030552	cAMP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003824	catalytic activity	IEA	molecular function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	TAS	molecular function
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	IEA	molecular function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0010754	negative regulation of cGMP-mediated signaling	IEA	biological process
GO:0043949	regulation of cAMP-mediated signaling	IEA	biological process
GO:0010738	regulation of protein kinase A signaling	IEA	biological process
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	molecular function
GO:0043951	negative regulation of cAMP-mediated signaling	IEA	biological process
GO:0043204	perikaryon	IEA	cellular component
GO:0043025	neuronal cell body	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0004112	cyclic-nucleotide phosphodiesterase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006198	cAMP catabolic process	IEA	biological process
GO:0046069	cGMP catabolic process	IEA	biological process
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA	molecular function
GO:0030552	cAMP binding	IDA	molecular function
GO:0030552	cAMP binding	NAS	molecular function
GO:0030553	cGMP binding	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04024	cAMP signaling pathway
hsa00230	Purine metabolism
hsa05032	Morphine addiction

Diseases

Associated diseases	References
Autosomal dominant striatal degeneration	KEGG:H01570
Infantile-onset limb and orofacial dyskinesia	KEGG:H02388
Autosomal dominant striatal degeneration	KEGG:H01570
Infantile-onset limb and orofacial dyskinesia	KEGG:H02388
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray