• Gene id: 10844

Gene Summary

• Gene Symbol: TUBGCP2   Gene   UCSC   Ensembl
• Aliases: ALP4, GCP-2, GCP2, Grip103, PAMDDFS, SPBC97, SPC97, Spc97p, h103p, hGCP2, hSpc97
• Gene name: tubulin gamma complex associated protein 2
• Alternate names: gamma-tubulin complex component 2, gamma-ring complex protein 103 kDa, hGrip103, spindle pole body protein Spc97 homolog,
• Gene location: 10q26.3 (133312336: 133278629)     Exons: 20     NC_000010.11
• OMIM: 300508

Protein Summary

• Protein general information: Q9BSJ2  
  • Name: Gamma tubulin complex component 2 (GCP 2) (hGCP2) (Gamma ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)
  • Length: 902  
  • Mass: 102534
  • Tissue specificity: Ubiquitously expressed.
• Sequence:

  MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELKSKNT
  RNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSINVPAAASKISMQELEELRKQLGSVATGSTL
  QQSLELKRKMLRDKQNKKNSGQHLPIFPAWVYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVVEDLLYVL
  VGVDGRYVSAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLV
  KEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLHDRSFSYTGDSQAQEL
  CLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKI
  LSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQG
  DFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAM
  AHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQW
  FAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLTNPELLKVFSK
  LMSVCVMFTNCMQKFTQSMKLDGELGGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKF
  DKNFSAHLLDLLARLSIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVT
  AQ

• Structural information:
  • Interpro: IPR007259  IPR040457  IPR041470  
  • PDB: 6V6B 6V6S
  • PDBsum: 6V6B 6V6S
  • STRING: ENSP00000446093
• Other Databases: GeneCards:  TUBGCP2  Malacards:  TUBGCP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051415	microtubule nucleation by interphase microtubule organizing center	IBA	biological process
GO:0051321	meiotic cell cycle	IBA	biological process
GO:0031122	cytoplasmic microtubule organization	IBA	biological process
GO:0008275	gamma-tubulin small complex	IBA	cellular component
GO:0005813	centrosome	IBA	cellular component
GO:0000923	equatorial microtubule organizing center	IBA	cellular component
GO:0000278	mitotic cell cycle	IBA	biological process
GO:0051225	spindle assembly	IBA	biological process
GO:0051011	microtubule minus-end binding	IBA	contributes to
GO:0043015	gamma-tubulin binding	IBA	molecular function
GO:0000930	gamma-tubulin complex	IBA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0005815	microtubule organizing center	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007020	microtubule nucleation	IEA	biological process
GO:0000226	microtubule cytoskeleton organization	IEA	biological process
GO:0000922	spindle pole	IEA	cellular component
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0043015	gamma-tubulin binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005815	microtubule organizing center	TAS	cellular component
GO:0005881	cytoplasmic microtubule	TAS	cellular component
GO:0065003	protein-containing complex assembly	TAS	biological process
GO:0007020	microtubule nucleation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005815	microtubule organizing center	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005813	centrosome	IDA	cellular component
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray