• Gene id: 10809

Gene Summary

• Gene Symbol: STARD10   Gene   UCSC   Ensembl
• Aliases: CGI-52, NY-CO-28, PCTP2, SDCCAG28
• Gene name: StAR related lipid transfer domain containing 10
• Alternate names: START domain-containing protein 10, PCTP-L, PCTP-like protein, START domain containing 10, StAR-related lipid transfer (START) domain containing 10, antigen NY-CO-28, serologically defined colon cancer antigen 28, stAR-related lipid transfer protein 10,
• Gene location: 11q13.4 (72793704: 72754728)     Exons: 2     NC_000011.10
• OMIM: 617382

Protein Summary

• Protein general information: Q9Y365  
  • Name: START domain containing protein 10 (StARD10) (Antigen NY CO 28) (PCTP like protein) (PCTP L) (Serologically defined colon cancer antigen 28) (StAR related lipid transfer protein 10)
  • Length: 291  
  • Mass: 33049
• Sequence:

  MEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVGWNLTYSRAGVSVWVQAVEMDRTLHKIKCRMECC
  DVPAETLYDVLHDIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSV
  KHPKYPPRKDLVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKACLKYPEW
  KQKHLPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVAESREERMGGAGGEGSDDDTSLT

• Structural information:
  • Protein Domains: (14..22-)
    (/note="START-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00197"-)
  • Interpro: IPR041951  IPR023393  IPR002913  
  • Prosite: PS50848
  • CDD: cd08871
  • STRING: ENSP00000335247
• Other Databases: GeneCards:  STARD10  Malacards:  STARD10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005902	microvillus	IBA	cellular component
GO:0005829	cytosol	IBA	cellular component
GO:0046581	intercellular canaliculus	IBA	cellular component
GO:0016020	membrane	IBA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006869	lipid transport	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006656	phosphatidylcholine biosynthetic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0046581	intercellular canaliculus	IEA	cellular component
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	IEA	biological process
GO:0032782	bile acid secretion	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005902	microvillus	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0031514	motile cilium	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray