• Gene id: 10795

Gene Summary

• Gene Symbol: ZNF268   Gene   UCSC   Ensembl
• Aliases: HZF3
• Gene name: zinc finger protein 268
• Alternate names: zinc finger protein 268, zinc finger protein 3, zinc finger protein HZF3,
• Gene location: 12q24.33 (133181494: 133214831)     Exons: 7     NC_000012.12
• OMIM: 604753

Protein Summary

• Protein general information: Q14587  
  • Name: Zinc finger protein 268 (Zinc finger protein HZF3)
  • Length: 947  
  • Mass: 108374
  • Tissue specificity: Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in b
• Sequence:

  MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKIT
  KSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQT
  CPNTVWKIDDLMDWHQENKDKLGSTAKSFECTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPN
  GFQVHGKSFFHSKHEQTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAE
  EKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPYECCECGKVFSRKDQL
  VSHQKTHSGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCG
  KAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGE
  KLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLI
  IHQRTHTGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKGVHTGVKPYGCSQCAK
  TFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTGEKPHECRECGKSFSFNSQLIVHQRIHTGEN
  PYECSECGKAFNRKDQLISHQRTHAGEKPYGCSECGKAFSSKSYLIIHMRTHSGEKPYECNECGKAFIWKSLLIV
  HERTHAGVNPYKCSQCEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKT
  FSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH

• Structural information:
  • Protein Domains: (81..15-)
    (/note="KRAB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00119"-)
  • Interpro: IPR001909  IPR036051  IPR036236  IPR013087  
  • Prosite: PS50805 PS00028 PS50157
  • CDD: cd07765
  • PDB: 2EL4 2EL5 2EL6 2EM1 2EMV 2EMW 2EMX 2EMY 2EN0 2EN6 2EN7 2EOF 2EOG 2EOI 2EOJ 2EOK 2EOL 2EOP 2EPV 2EPW 2EPY 2YTF 2YTQ
  • PDBsum: 2EL4 2EL5 2EL6 2EM1 2EMV 2EMW 2EMX 2EMY 2EN0 2EN6 2EN7 2EOF 2EOG 2EOI 2EOJ 2EOK 2EOL 2EOP 2EPV 2EPW 2EPY 2YTF 2YTQ
  • STRING: ENSP00000444412
• Other Databases: GeneCards:  ZNF268  Malacards:  ZNF268

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	biological process
GO:0071157	negative regulation of cell cycle arrest	IMP	biological process
GO:0045597	positive regulation of cell differentiation	IMP	biological process
GO:0043066	negative regulation of apoptotic process	IMP	biological process
GO:0030335	positive regulation of cell migration	IMP	biological process
GO:0008285	negative regulation of cell population proliferation	IMP	biological process
GO:0008285	negative regulation of cell population proliferation	IMP	biological process
GO:0008284	positive regulation of cell population proliferation	IMP	biological process
GO:0043065	positive regulation of apoptotic process	IMP	biological process
GO:0007346	regulation of mitotic cell cycle	IMP	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0015629	actin cytoskeleton	IDA	cellular component
GO:0003700	DNA-binding transcription factor activity	NAS	molecular function
GO:0005634	nucleus	NAS	cellular component
GO:0006355	regulation of transcription, DNA-templated	NAS	biological process
GO:0003677	DNA binding	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05168	Herpes simplex virus 1 infection

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)