• Gene id: 10788

Gene Summary

• Gene Symbol: IQGAP2   Gene   UCSC   Ensembl
• Gene name: IQ motif containing GTPase activating protein 2
• Alternate names: ras GTPase-activating-like protein IQGAP2,
• Gene location: 5q13.3 (76403284: 76708131)     Exons: 41     NC_000005.10
• Gene summary(Entrez): This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, an
• OMIM: 605401

Protein Summary

• Protein general information: Q13576  
  • Name: Ras GTPase activating like protein IQGAP2
  • Length: 1575  
  • Mass: 180578
  • Tissue specificity: Isoform 2 expression is enhanced in testis.
• Sequence:

  MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYL
  AKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIH
  ALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAV
  EKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK
  VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAV
  ALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEE
  NDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAV
  DDANVDKDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW
  LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPI
  LREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDH
  NNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDL
  NLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA
  KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGA
  RGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIEN
  LRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMT
  AGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL
  VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSK
  TEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTP
  EEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTL
  NALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT
  NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK

• Structural information:
  • Protein Domains: (41..15-)
    (/note="Calponin-homology-(CH))
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00044-)
    (594..62-)
    (/note="WW-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00224-)
    (690..71-)
    (/note="IQ-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PR-)
  • Interpro: IPR001715  IPR036872  IPR000048  IPR000593  IPR023152   IPR001936  IPR008936  IPR001202  
  • Prosite: PS50021 PS50096 PS00509 PS50018 PS01159 PS50020
  • CDD: cd00014
  • PDB: 3IEZ 4EZA 5CJP
  • PDBsum: 3IEZ 4EZA 5CJP
  • DIP: 27542
  • STRING: ENSP00000274364
• Other Databases: GeneCards:  IQGAP2  Malacards:  IQGAP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0032956	regulation of actin cytoskeleton organization	IBA	biological process
GO:0048365	Rac GTPase binding	IBA	molecular function
GO:0005516	calmodulin binding	IBA	molecular function
GO:0017016	Ras GTPase binding	IBA	molecular function
GO:0051015	actin filament binding	IBA	molecular function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IDA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0043087	regulation of GTPase activity	IEA	biological process
GO:0005516	calmodulin binding	IEA	molecular function
GO:0005095	GTPase inhibitor activity	TAS	molecular function
GO:0003779	actin binding	TAS	molecular function
GO:0007165	signal transduction	TAS	biological process
GO:0015629	actin cytoskeleton	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0030667	secretory granule membrane	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005902	microvillus	IEA	cellular component
GO:0034260	negative regulation of GTPase activity	IEA	biological process
GO:0034314	Arp2/3 complex-mediated actin nucleation	IDA	biological process
GO:0017048	Rho GTPase binding	IDA	molecular function
GO:0030175	filopodium	IDA	cellular component
GO:0030027	lamellipodium	IDA	cellular component
GO:0070493	thrombin-activated receptor signaling pathway	IDA	biological process
GO:0048365	Rac GTPase binding	IDA	molecular function
GO:0051015	actin filament binding	IDA	molecular function
GO:0071933	Arp2/3 complex binding	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:2000249	regulation of actin cytoskeleton reorganization	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0005516	calmodulin binding	IPI	molecular function
GO:0005516	calmodulin binding	IPI	molecular function
GO:0005516	calmodulin binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04810	Regulation of actin cytoskeleton

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray