• Gene id: 10777

Gene Summary

• Gene Symbol: ARPP21   Gene   UCSC   Ensembl
• Aliases: ARPP-21, R3HDM3, RCS, TARPP
• Gene name: cAMP regulated phosphoprotein 21
• Alternate names: cAMP-regulated phosphoprotein 21, R3H domain containing 3, cAMP regulated phosphoprotein 21kDa, cyclic AMP-regulated phosphoprotein, 21 kD, thymocyte cAMP-regulated phosphoprotein,
• Gene location: 3p22.3 (35639524: 35798932)     Exons: 28     NC_000003.12
• Gene summary(Entrez): This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing resu
• OMIM: 605488

Protein Summary

• Protein general information: Q9UBL0  
  • Name: cAMP regulated phosphoprotein 21 (ARPP 21) (Thymocyte cAMP regulated phosphoprotein)
  • Length: 812  
  • Mass: 89196
  • Tissue specificity: Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). {ECO
• Sequence:

  MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQRRLEAQNQERRKSKSGAGKGKLTRSLAVCEES
  SARPGGESLQDQESIHLQLSSFSSLQEEDKSRKDDSEREKEKDKNKDKTSEKPKIRMLSKDCSQEYTDSTGIDLH
  EFLINTLKNNSRDRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSVIINKTS
  STRIPEQRFCEHLKDEKGEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS
  VCSQESLFVENSRLLEDSNICNETYKKRQLFRGNRDGSGRTSGSRQSSSENELKWSDHQRAWSSTDSDSSNRNLK
  PAMTKTASFGGITVLTRGDSTSSTRSTGKLSKAGSESSSSAGSSGSLSRTHPPLQSTPLVSGVAAGSPGCVPYPE
  NGIGGQVAPSSTSYILLPLEAATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPTSQQPLRSAMVGQSQQQPPQQQ
  PSPQPQQQVQPPQPQMAGPLVTQRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQPAQQPSYVIASTGQQ
  LPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPSGQYPTSTTQQYRPMAPVQYNAQRSQQMPQAAQ
  QAGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQSVMVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPN
  QAGQGSLPATGMPVYCNVTPPTPQNNLRLIGPHCPSSTVPVMSASCRTNCASMSNAGWQVKF

• Structural information:
  • Protein Domains: (164..22-)
    (/note="R3H-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00382-)
    (228..30-)
    (/note="SUZ-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01009"-)
  • Interpro: IPR001374  IPR036867  IPR024771  
  • Prosite: PS51061 PS51673
  • STRING: ENSP00000412326
• Other Databases: GeneCards:  ARPP21  Malacards:  ARPP21

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0034605	cellular response to heat	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0005575	cellular_component	ND	cellular component
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq