• Gene id: 10766

Gene Summary

• Gene Symbol: TOB2   Gene   UCSC   Ensembl
• Aliases: APRO5, TOB4, TOBL, TROB2
• Gene name: transducer of ERBB2, 2
• Alternate names: protein Tob2, protein Tob4, transducer of erbB-2 2,
• Gene location: 22q13.2 (41448229: 41433491)     Exons: 3     NC_000022.11
• Gene summary(Entrez): TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
• OMIM: 604434

Protein Summary

• Protein general information: Q14106  
  • Name: Protein Tob2 (Protein Tob4) (Transducer of erbB 2 2)
  • Length: 344  
  • Mass: 36632
  • Tissue specificity: Ubiquitous.
• Sequence:

  MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHIGEMVDPVVELAAKRS
  GLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGCGAPELDKEIKSSFNPDAQVFVPIGSQDSSL
  SNSPSPSFGQSPSPTFIPRSAQPITFTTASFAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTN
  SLLKHKSLSLSMHSLNFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPFGGSGAGTCNSSSFD
  MAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQQFQPVVLAN

• Structural information:
  • Interpro: IPR002087  IPR009818  IPR036054  IPR015676  IPR015678  
  • Prosite: PS00960 PS01203
  • DIP: 41990
  • STRING: ENSP00000331305
• Other Databases: GeneCards:  TOB2  Malacards:  TOB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003714	transcription corepressor activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0010468	regulation of gene expression	IBA	biological process
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007292	female gamete generation	TAS	biological process
GO:0005634	nucleus	TAS	cellular component
GO:0008285	negative regulation of cell population proliferation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0045778	positive regulation of ossification	IEA	biological process
GO:0045671	negative regulation of osteoclast differentiation	IEA	biological process
GO:0042809	vitamin D receptor binding	IEA	molecular function
GO:0010468	regulation of gene expression	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:1903507	negative regulation of nucleic acid-templated transcription	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa03018	RNA degradation

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R