• Gene id: 10763

Gene Summary

• Gene Symbol: NES   Gene   UCSC   Ensembl
• Aliases: Nbla00170
• Gene name: nestin
• Alternate names: nestin,
• Gene location: 1q23.1 (156677406: 156668762)     Exons: 4     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
• OMIM: 613467

Protein Summary

• Protein general information: P48681  
  • Name: Nestin
  • Length: 1621  
  • Mass: 177439
  • Tissue specificity: CNS stem cells.
• Sequence:

  MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKH
  AAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVG
  LNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLEL
  QQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA
  TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQ
  EFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQ
  RQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWE
  EEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDV
  EVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQ
  EPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQ
  DQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEI
  LESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNL
  ENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENE
  DEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGA
  PGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLE
  EESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAP
  SPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGP
  QEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKE
  EGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEED
  QEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEE
  ESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPLVSEGDR
  GSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGED

• Structural information:
  • Protein Domains: (8..31-)
    (/note="IF-rod)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01188"-)
  • Interpro: IPR018039  IPR039008  IPR042180  IPR031211  
  • Prosite: PS00226 PS51842
  • STRING: ENSP00000357206
• Other Databases: GeneCards:  NES  Malacards:  NES

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005882	intermediate filament	IBA	cellular component
GO:0031730	CCR5 chemokine receptor binding	IBA	molecular function
GO:0030844	positive regulation of intermediate filament depolymerization	IBA	biological process
GO:0072089	stem cell proliferation	IMP	biological process
GO:0000086	G2/M transition of mitotic cell cycle	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0019215	intermediate filament binding	IEA	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0005882	intermediate filament	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048858	cell projection morphogenesis	IEA	biological process
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0005882	intermediate filament	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0045111	intermediate filament cytoskeleton	IDA	cellular component
GO:0043086	negative regulation of catalytic activity	IDA	biological process
GO:0032091	negative regulation of protein binding	IDA	biological process
GO:0030844	positive regulation of intermediate filament depolymerization	ISS	biological process
GO:0007417	central nervous system development	NAS	biological process
GO:0019215	intermediate filament binding	ISS	molecular function
GO:0003674	molecular_function	ND	molecular function
GO:2000179	positive regulation of neural precursor cell proliferation	ISS	biological process
GO:0031076	embryonic camera-type eye development	ISS	biological process
GO:0007420	brain development	ISS	biological process
GO:0005882	intermediate filament	NAS	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R